Matches in SemOpenAlex for { <https://semopenalex.org/work/W2136914517> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2136914517 endingPage "507" @default.
- W2136914517 startingPage "506" @default.
- W2136914517 abstract "The excessive use of β2 agonists has been associated with increased asthma mortality, although this seems to be due to confounding by disease severity rather than direct drug toxicity.1 2 Dose-response studies in stable asthmatics have shown the potential for high doses of salbutamol to produce direct or indirect cardiovascular sequelae mediated by extrapulmonary β2 adrenoceptor stimulation including chronotropic and inotropic activity, peripheral vasodilatation, electrocardiographic changes, as well as hypokalaemia and hypomagnesaemia.3 4 The potential for cardiovascular toxicity with high doses of inhaled β2 agonists may be considered in the context of “the seed and the soil”. In terms of the “seed”, there are conflicting reports as to whether a full agonist such as fenoterol produces greater dose related systemic β2 mediated systemic effects than a partial agonist such as salbutamol in asthmatic patients when comparing microgram equivalent doses with the same bronchodilator potency.4-6 In terms of the “soil” for salbutamol mediated adverse effects, concomitant diuretic therapy may augment hypokalaemic and electrocardiographic sequelae, concomitant corticosteroid may sensitise cardiac β2 adrenoceptors, while the elderly exhibit increased chronotropy and peripheral vasodilatation.7-9 Patients with more severe asthma have reduced systemic effects of salbutamol due to reduced lung absorption so they may, in effect, be protecting themselves from adverse effects.10 The lung absorption of salbutamol may …" @default.
- W2136914517 created "2016-06-24" @default.
- W2136914517 creator A5054519215 @default.
- W2136914517 date "2001-07-01" @default.
- W2136914517 modified "2023-10-18" @default.
- W2136914517 title "Revisiting interactions between hypoxaemia and beta2 agonists in asthma" @default.
- W2136914517 cites W1966317355 @default.
- W2136914517 cites W1968141933 @default.
- W2136914517 cites W1977307635 @default.
- W2136914517 cites W1989687861 @default.
- W2136914517 cites W2003816831 @default.
- W2136914517 cites W2012036205 @default.
- W2136914517 cites W2019061463 @default.
- W2136914517 cites W2030453913 @default.
- W2136914517 cites W2065252328 @default.
- W2136914517 cites W2071277880 @default.
- W2136914517 cites W2074726334 @default.
- W2136914517 cites W2085297573 @default.
- W2136914517 cites W2086313465 @default.
- W2136914517 cites W2102877087 @default.
- W2136914517 cites W2117220738 @default.
- W2136914517 cites W2125572415 @default.
- W2136914517 cites W2126169750 @default.
- W2136914517 cites W2142674313 @default.
- W2136914517 cites W2147216774 @default.
- W2136914517 cites W2150114083 @default.
- W2136914517 cites W2276769406 @default.
- W2136914517 cites W2334701948 @default.
- W2136914517 cites W2805738935 @default.
- W2136914517 cites W2474555412 @default.
- W2136914517 doi "https://doi.org/10.1136/thorax.56.7.506" @default.
- W2136914517 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1746087" @default.
- W2136914517 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11413346" @default.
- W2136914517 hasPublicationYear "2001" @default.
- W2136914517 type Work @default.
- W2136914517 sameAs 2136914517 @default.
- W2136914517 citedByCount "12" @default.
- W2136914517 countsByYear W21369145172015 @default.
- W2136914517 countsByYear W21369145172017 @default.
- W2136914517 crossrefType "journal-article" @default.
- W2136914517 hasAuthorship W2136914517A5054519215 @default.
- W2136914517 hasBestOaLocation W21369145172 @default.
- W2136914517 hasConcept C126322002 @default.
- W2136914517 hasConcept C170493617 @default.
- W2136914517 hasConcept C177713679 @default.
- W2136914517 hasConcept C2776042228 @default.
- W2136914517 hasConcept C2778938600 @default.
- W2136914517 hasConcept C2779591629 @default.
- W2136914517 hasConcept C2781018748 @default.
- W2136914517 hasConcept C2909082692 @default.
- W2136914517 hasConcept C2909548125 @default.
- W2136914517 hasConcept C3017940444 @default.
- W2136914517 hasConcept C71924100 @default.
- W2136914517 hasConceptScore W2136914517C126322002 @default.
- W2136914517 hasConceptScore W2136914517C170493617 @default.
- W2136914517 hasConceptScore W2136914517C177713679 @default.
- W2136914517 hasConceptScore W2136914517C2776042228 @default.
- W2136914517 hasConceptScore W2136914517C2778938600 @default.
- W2136914517 hasConceptScore W2136914517C2779591629 @default.
- W2136914517 hasConceptScore W2136914517C2781018748 @default.
- W2136914517 hasConceptScore W2136914517C2909082692 @default.
- W2136914517 hasConceptScore W2136914517C2909548125 @default.
- W2136914517 hasConceptScore W2136914517C3017940444 @default.
- W2136914517 hasConceptScore W2136914517C71924100 @default.
- W2136914517 hasIssue "7" @default.
- W2136914517 hasLocation W21369145171 @default.
- W2136914517 hasLocation W21369145172 @default.
- W2136914517 hasLocation W21369145173 @default.
- W2136914517 hasLocation W21369145174 @default.
- W2136914517 hasOpenAccess W2136914517 @default.
- W2136914517 hasPrimaryLocation W21369145171 @default.
- W2136914517 hasRelatedWork W2004355551 @default.
- W2136914517 hasRelatedWork W2089418505 @default.
- W2136914517 hasRelatedWork W2097591149 @default.
- W2136914517 hasRelatedWork W2114578395 @default.
- W2136914517 hasRelatedWork W2362244286 @default.
- W2136914517 hasRelatedWork W2414065349 @default.
- W2136914517 hasRelatedWork W2462693500 @default.
- W2136914517 hasRelatedWork W2522773605 @default.
- W2136914517 hasRelatedWork W4235375593 @default.
- W2136914517 hasRelatedWork W4307029756 @default.
- W2136914517 hasVolume "56" @default.
- W2136914517 isParatext "false" @default.
- W2136914517 isRetracted "false" @default.
- W2136914517 magId "2136914517" @default.
- W2136914517 workType "article" @default.