FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2136921063> ?p ?o ?g. }

• W2136921063 endingPage "203" @default.
• W2136921063 startingPage "186" @default.
• W2136921063 abstract "The pentameric ATPase motor gp16 packages double-stranded DNA into the bacteriophage ϕ29 virus capsid. On the basis of the results of single-molecule experimental studies, we propose a push and roll mechanism to explain how the packaging motor translocates the DNA in bursts of four 2.5 bp power strokes, while rotating the DNA. In this mechanism, each power stroke accompanies Pi release after ATP hydrolysis. Since the high-resolution structure of the gp16 motor is not available, we borrowed characterized features from the P4 RNA packaging motor in bacteriophage ϕ12. For each power stroke, a lumenal lever from a single subunit is electrostatically steered to the DNA backbone. The lever then pushes sterically, orthogonal to the backbone axis, such that the right-handed DNA helix is translocated and rotated in a left-handed direction. The electrostatic association allows tight coupling between the lever and the DNA and prevents DNA from slipping back. The lever affinity for DNA decreases towards the end of the power stroke and the DNA rolls to the lever on the next subunit. Each power stroke facilitates ATP hydrolysis in the next catalytic site by inserting an Arg -finger into the site, as captured in ϕ12-P4. At the end of every four power strokes, ADP release happens slowly, so the cycle pauses constituting a dwell phase during which four ATPs are loaded into the catalytic sites. The next burst phase of four power strokes starts once spontaneous ATP hydrolysis takes place in the fifth site without insertion of an Arg finger. The push and roll model provides a new perspective on how a multimeric ATPase transports DNA, and it might apply to other ring motors as well." @default.
• W2136921063 created "2016-06-24" @default.
• W2136921063 creator A5000135837 @default.
• W2136921063 creator A5010743284 @default.
• W2136921063 creator A5017454018 @default.
• W2136921063 creator A5041126355 @default.
• W2136921063 creator A5087838801 @default.
• W2136921063 date "2010-07-01" @default.
• W2136921063 modified "2023-10-16" @default.
• W2136921063 title "Mechanochemistry of a Viral DNA Packaging Motor" @default.
• W2136921063 cites W124504601 @default.
• W2136921063 cites W1531152013 @default.
• W2136921063 cites W1541514857 @default.
• W2136921063 cites W1557627802 @default.
• W2136921063 cites W1591841333 @default.
• W2136921063 cites W1893057187 @default.
• W2136921063 cites W1938988497 @default.
• W2136921063 cites W1955320271 @default.
• W2136921063 cites W1965415521 @default.
• W2136921063 cites W1967736967 @default.
• W2136921063 cites W1970674743 @default.
• W2136921063 cites W1991976083 @default.
• W2136921063 cites W2000410597 @default.
• W2136921063 cites W2000945774 @default.
• W2136921063 cites W2001138638 @default.
• W2136921063 cites W2016517517 @default.
• W2136921063 cites W2019531132 @default.
• W2136921063 cites W2024480366 @default.
• W2136921063 cites W2025505853 @default.
• W2136921063 cites W2029667189 @default.
• W2136921063 cites W2030525804 @default.
• W2136921063 cites W2030864530 @default.
• W2136921063 cites W2033087969 @default.
• W2136921063 cites W2035055416 @default.
• W2136921063 cites W2036842869 @default.
• W2136921063 cites W2039179882 @default.
• W2136921063 cites W2040991028 @default.
• W2136921063 cites W2046037398 @default.
• W2136921063 cites W2047660022 @default.
• W2136921063 cites W2051762335 @default.
• W2136921063 cites W2051944068 @default.
• W2136921063 cites W2055544854 @default.
• W2136921063 cites W2059531322 @default.
• W2136921063 cites W2073488873 @default.
• W2136921063 cites W2076602648 @default.
• W2136921063 cites W2079273943 @default.
• W2136921063 cites W2092348814 @default.
• W2136921063 cites W2093707543 @default.
• W2136921063 cites W2095713223 @default.
• W2136921063 cites W2098030850 @default.
• W2136921063 cites W2103808129 @default.
• W2136921063 cites W2104097315 @default.
• W2136921063 cites W2125053230 @default.
• W2136921063 cites W2126023294 @default.
• W2136921063 cites W2127332054 @default.
• W2136921063 cites W2132659102 @default.
• W2136921063 cites W2135985505 @default.
• W2136921063 cites W2145618349 @default.
• W2136921063 cites W2147827238 @default.
• W2136921063 cites W2148893509 @default.
• W2136921063 cites W2149308779 @default.
• W2136921063 cites W2152041017 @default.
• W2136921063 cites W2153597220 @default.
• W2136921063 cites W2167320414 @default.
• W2136921063 cites W2169206053 @default.
• W2136921063 cites W2170353382 @default.
• W2136921063 cites W2583347981 @default.
• W2136921063 doi "https://doi.org/10.1016/j.jmb.2010.05.002" @default.
• W2136921063 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20452360" @default.
• W2136921063 hasPublicationYear "2010" @default.
• W2136921063 type Work @default.
• W2136921063 sameAs 2136921063 @default.
• W2136921063 citedByCount "76" @default.
• W2136921063 countsByYear W21369210632012 @default.
• W2136921063 countsByYear W21369210632013 @default.
• W2136921063 countsByYear W21369210632014 @default.
• W2136921063 countsByYear W21369210632015 @default.
• W2136921063 countsByYear W21369210632016 @default.
• W2136921063 countsByYear W21369210632017 @default.
• W2136921063 countsByYear W21369210632018 @default.
• W2136921063 countsByYear W21369210632019 @default.
• W2136921063 countsByYear W21369210632020 @default.
• W2136921063 countsByYear W21369210632021 @default.
• W2136921063 countsByYear W21369210632023 @default.
• W2136921063 crossrefType "journal-article" @default.
• W2136921063 hasAuthorship W2136921063A5000135837 @default.
• W2136921063 hasAuthorship W2136921063A5010743284 @default.
• W2136921063 hasAuthorship W2136921063A5017454018 @default.
• W2136921063 hasAuthorship W2136921063A5041126355 @default.
• W2136921063 hasAuthorship W2136921063A5087838801 @default.
• W2136921063 hasConcept C104317684 @default.
• W2136921063 hasConcept C107524782 @default.
• W2136921063 hasConcept C121332964 @default.
• W2136921063 hasConcept C12554922 @default.
• W2136921063 hasConcept C141315368 @default.
• W2136921063 hasConcept C160408235 @default.
• W2136921063 hasConcept C181199279 @default.
• W2136921063 hasConcept C185592680 @default.

• next