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- W2136945849 abstract "Six similar experiments were conducted with a total of 208 female rats to determine the effect of the level (10, 18, 27, and 36%) of protein intake on growth. The effect of level of protein intake on longevity was also observed in 160 of the rats. All rats were fed an 18% casein diet for 1 week after weaning and then were separated into three or four dietary groups. Littermates were evenly distributed in the different groups. The increases in both tail length and body weight of rats fed a 10% casein diet were generally less than those of the rats fed the higher levels of protein, especially in weeks 8 to 10 after birth. This difference gradually decreased and became insignificant by the end of the growth period. The effect of level of protein on the biochemical measures (urinary excretion of creatinine, hydroxyproline and 17-ketosteroids, and the serum alkaline phosphatase activity) observed in the early period of growth among the four groups became obscure by the end of the growth period. In brief, the growth rate varied directly with the protein intake in the early period, but eventually the differences observed among the groups became insignificant. However, the effect of variance of litters was equal to or greater than that of difference in diet. Diet and the differences among litters had no effect on longevity. The number of lesions observed at death did not differ among the groups. In one experiment, however, the incidence of lesions in the spleen and the number of mammary tumors seemed to be greater in the groups fed a high protein diet." @default.
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- W2136945849 date "1974-12-01" @default.
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- W2136945849 title "Effect of Protein Nutrition on Growth, Longevity and Incidence of Lesions in the Rat" @default.
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- W2136945849 doi "https://doi.org/10.1093/jn/104.12.1576" @default.
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