FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2136959892> ?p ?o ?g. }

• W2136959892 endingPage "81" @default.
• W2136959892 startingPage "75" @default.
• W2136959892 abstract "Wnt genes regulate a diverse range of developmental processes, including placental formation. Activation of the WNT pathway results in translocation of beta-catenin (CTNNB1) into the nucleus and the subsequent activation of transcription factors that promote proliferation. The secreted frizzled related proteins (SFRPs) are thought to inhibit WNT signaling by binding to the WNT ligand or its frizzled receptor. In this study, we compared the expression patterns of one of these secreted molecules, SFRP4, in the two morphologically and functionally distinct regions of the rat placenta during the last third of pregnancy. In addition, we assessed whether placental SFRP4 expression is altered in a model of glucocorticoid-induced placental growth restriction. Temporal analyses of the rat placenta by quantitative RT-PCR, in situ hybridization, and immunohistochemistry during the final third of pregnancy demonstrated elevated levels of Sfrp4 mRNA and SFRP4 protein near term, specifically in trophoblast cells of the basal zone. This increase in expression of SFRP4 in basal zone trophoblasts was associated with a reduction in CTNNB1 nuclear translocation, consistent with inhibition of the WNT pathway. Maternal dexamethasone treatment (1 μg/ml of drinking water, Days 13–22), which has previously been shown to reduce placental growth, further increased the expression of Sfrp4 mRNA in both the basal and labyrinth zones of the placenta at Day 22. Collectively, these data demonstrate that increased expression of SFRP4 is associated with reduced growth of placental regions in normal pregnancy and after glucocorticoid-induced growth retardation. These observations, together with associated changes in CTNNB1 localization, support the hypothesis that increased placental expression of SFRP4 inhibits the WNT pathway and thereby influences placental growth via effects on cell fate signaling." @default.
• W2136959892 created "2016-06-24" @default.
• W2136959892 creator A5025906583 @default.
• W2136959892 creator A5040600749 @default.
• W2136959892 creator A5059905500 @default.
• W2136959892 creator A5075796355 @default.
• W2136959892 date "2006-07-01" @default.
• W2136959892 modified "2023-10-13" @default.
• W2136959892 title "Placental Expression of Secreted Frizzled Related Protein-4 in the Rat and the Impact of Glucocorticoid-Induced Fetal and Placental Growth Restriction" @default.
• W2136959892 cites W1518164493 @default.
• W2136959892 cites W1964027376 @default.
• W2136959892 cites W1965919073 @default.
• W2136959892 cites W1979132962 @default.
• W2136959892 cites W1982709013 @default.
• W2136959892 cites W1984126393 @default.
• W2136959892 cites W2006797091 @default.
• W2136959892 cites W2014627257 @default.
• W2136959892 cites W2018448892 @default.
• W2136959892 cites W2019361870 @default.
• W2136959892 cites W2021612893 @default.
• W2136959892 cites W2023084445 @default.
• W2136959892 cites W2025656285 @default.
• W2136959892 cites W2027740888 @default.
• W2136959892 cites W2038131544 @default.
• W2136959892 cites W2038623988 @default.
• W2136959892 cites W2051235811 @default.
• W2136959892 cites W2052620994 @default.
• W2136959892 cites W2055695273 @default.
• W2136959892 cites W2058247916 @default.
• W2136959892 cites W2060655996 @default.
• W2136959892 cites W2061999678 @default.
• W2136959892 cites W2066078074 @default.
• W2136959892 cites W2067561333 @default.
• W2136959892 cites W2073974662 @default.
• W2136959892 cites W2076487095 @default.
• W2136959892 cites W2079087587 @default.
• W2136959892 cites W2082948795 @default.
• W2136959892 cites W2105382341 @default.
• W2136959892 cites W2106330601 @default.
• W2136959892 cites W2116434858 @default.
• W2136959892 cites W2116599453 @default.
• W2136959892 cites W2119437828 @default.
• W2136959892 cites W2131299724 @default.
• W2136959892 cites W2134671512 @default.
• W2136959892 cites W2141681777 @default.
• W2136959892 cites W2148294117 @default.
• W2136959892 cites W2150000725 @default.
• W2136959892 cites W2150208524 @default.
• W2136959892 cites W2167638513 @default.
• W2136959892 cites W2167950650 @default.
• W2136959892 cites W2171410951 @default.
• W2136959892 cites W2315382108 @default.
• W2136959892 cites W4210953733 @default.
• W2136959892 cites W4211089574 @default.
• W2136959892 doi "https://doi.org/10.1095/biolreprod.105.047647" @default.
• W2136959892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16540541" @default.
• W2136959892 hasPublicationYear "2006" @default.
• W2136959892 type Work @default.
• W2136959892 sameAs 2136959892 @default.
• W2136959892 citedByCount "33" @default.
• W2136959892 countsByYear W21369598922012 @default.
• W2136959892 countsByYear W21369598922013 @default.
• W2136959892 countsByYear W21369598922014 @default.
• W2136959892 countsByYear W21369598922015 @default.
• W2136959892 countsByYear W21369598922016 @default.
• W2136959892 countsByYear W21369598922017 @default.
• W2136959892 countsByYear W21369598922018 @default.
• W2136959892 countsByYear W21369598922019 @default.
• W2136959892 countsByYear W21369598922021 @default.
• W2136959892 countsByYear W21369598922022 @default.
• W2136959892 countsByYear W21369598922023 @default.
• W2136959892 crossrefType "journal-article" @default.
• W2136959892 hasAuthorship W2136959892A5025906583 @default.
• W2136959892 hasAuthorship W2136959892A5040600749 @default.
• W2136959892 hasAuthorship W2136959892A5059905500 @default.
• W2136959892 hasAuthorship W2136959892A5075796355 @default.
• W2136959892 hasBestOaLocation W21369598921 @default.
• W2136959892 hasConcept C104317684 @default.
• W2136959892 hasConcept C107300179 @default.
• W2136959892 hasConcept C126322002 @default.
• W2136959892 hasConcept C134018914 @default.
• W2136959892 hasConcept C137620995 @default.
• W2136959892 hasConcept C150194340 @default.
• W2136959892 hasConcept C172680121 @default.
• W2136959892 hasConcept C2776953305 @default.
• W2136959892 hasConcept C2777495146 @default.
• W2136959892 hasConcept C2779234561 @default.
• W2136959892 hasConcept C2780841215 @default.
• W2136959892 hasConcept C54355233 @default.
• W2136959892 hasConcept C59493245 @default.
• W2136959892 hasConcept C62478195 @default.
• W2136959892 hasConcept C71924100 @default.
• W2136959892 hasConcept C81439078 @default.
• W2136959892 hasConcept C86803240 @default.
• W2136959892 hasConcept C95444343 @default.
• W2136959892 hasConceptScore W2136959892C104317684 @default.
• W2136959892 hasConceptScore W2136959892C107300179 @default.
• W2136959892 hasConceptScore W2136959892C126322002 @default.

• next