FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2136970654> ?p ?o ?g. }

• W2136970654 endingPage "398" @default.
• W2136970654 startingPage "392" @default.
• W2136970654 abstract "Congenital disorders of glycosylation (CDGs) result from mutations in various N-glycosylation genes. The most common type, phosphomannomutase-2 (PMM2)-CDG (CDG-Ia), is due to deficient PMM2 (Man-6-P → Man-1-P). Many patients die from recurrent infections, but the mechanism is unknown. We found that glycosylation-deficient patient fibroblasts have less intercellular adhesion molecule-1 (ICAM-1), and because of its role in innate immune response, we hypothesized that its reduction might help explain recurrent infections in CDG patients. We, therefore, studied mice with mutations in Mpi encoding phosphomannose isomerase (Fru-6-P → Man-6-P), the cause of human MPI-CDG. We challenged MPI-deficient mice with an intraperitoneal injection of zymosan to induce an inflammatory response and found decreased neutrophil extravasation compared with control mice. Immunohistochemistry of mesenteries showed attenuated neutrophil egress, presumably due to poor ICAM-1 response to acute peritonitis. Since phosphomannose isomerase (MPI)-CDG patients and their cells improve glycosylation when given mannose, we provided MPI-deficient mice with mannose-supplemented water for 7 days. This restored ICAM-1 expression on mesenteric endothelial cells and enhanced transendothelial migration of neutrophils during acute inflammation. Attenuated inflammatory response in glycosylation-deficient mice may result from a failure to increase ICAM-1 on the vascular endothelial surface and may help explain recurrent infections in patients." @default.
• W2136970654 created "2016-06-24" @default.
• W2136970654 creator A5026885060 @default.
• W2136970654 creator A5041686137 @default.
• W2136970654 creator A5063846120 @default.
• W2136970654 date "2014-01-28" @default.
• W2136970654 modified "2023-10-03" @default.
• W2136970654 title "N-glycosylation deficiency reduces ICAM-1 induction and impairs inflammatory response" @default.
• W2136970654 cites W1545973549 @default.
• W2136970654 cites W1593552847 @default.
• W2136970654 cites W1889065105 @default.
• W2136970654 cites W1966286149 @default.
• W2136970654 cites W1977997956 @default.
• W2136970654 cites W1979598002 @default.
• W2136970654 cites W1985033280 @default.
• W2136970654 cites W1988142527 @default.
• W2136970654 cites W1988952956 @default.
• W2136970654 cites W1990117583 @default.
• W2136970654 cites W2017492126 @default.
• W2136970654 cites W2021458684 @default.
• W2136970654 cites W2021633743 @default.
• W2136970654 cites W2023418900 @default.
• W2136970654 cites W2026466666 @default.
• W2136970654 cites W2036656454 @default.
• W2136970654 cites W2048764560 @default.
• W2136970654 cites W2072042565 @default.
• W2136970654 cites W2075295969 @default.
• W2136970654 cites W2085869287 @default.
• W2136970654 cites W2086487142 @default.
• W2136970654 cites W2088220499 @default.
• W2136970654 cites W2093830420 @default.
• W2136970654 cites W2099211139 @default.
• W2136970654 cites W2102237385 @default.
• W2136970654 cites W2128606509 @default.
• W2136970654 cites W2130895038 @default.
• W2136970654 cites W2131547680 @default.
• W2136970654 cites W2134138329 @default.
• W2136970654 cites W2151403120 @default.
• W2136970654 cites W2152034648 @default.
• W2136970654 cites W2161769648 @default.
• W2136970654 cites W2213537831 @default.
• W2136970654 cites W2332565014 @default.
• W2136970654 doi "https://doi.org/10.1093/glycob/cwu006" @default.
• W2136970654 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3954120" @default.
• W2136970654 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24474243" @default.
• W2136970654 hasPublicationYear "2014" @default.
• W2136970654 type Work @default.
• W2136970654 sameAs 2136970654 @default.
• W2136970654 citedByCount "28" @default.
• W2136970654 countsByYear W21369706542014 @default.
• W2136970654 countsByYear W21369706542015 @default.
• W2136970654 countsByYear W21369706542016 @default.
• W2136970654 countsByYear W21369706542017 @default.
• W2136970654 countsByYear W21369706542018 @default.
• W2136970654 countsByYear W21369706542019 @default.
• W2136970654 countsByYear W21369706542020 @default.
• W2136970654 countsByYear W21369706542021 @default.
• W2136970654 countsByYear W21369706542022 @default.
• W2136970654 crossrefType "journal-article" @default.
• W2136970654 hasAuthorship W2136970654A5026885060 @default.
• W2136970654 hasAuthorship W2136970654A5041686137 @default.
• W2136970654 hasAuthorship W2136970654A5063846120 @default.
• W2136970654 hasBestOaLocation W21369706541 @default.
• W2136970654 hasConcept C136449434 @default.
• W2136970654 hasConcept C185592680 @default.
• W2136970654 hasConcept C203014093 @default.
• W2136970654 hasConcept C2776914184 @default.
• W2136970654 hasConcept C2777313579 @default.
• W2136970654 hasConcept C55493867 @default.
• W2136970654 hasConcept C71924100 @default.
• W2136970654 hasConcept C86803240 @default.
• W2136970654 hasConcept C8891405 @default.
• W2136970654 hasConceptScore W2136970654C136449434 @default.
• W2136970654 hasConceptScore W2136970654C185592680 @default.
• W2136970654 hasConceptScore W2136970654C203014093 @default.
• W2136970654 hasConceptScore W2136970654C2776914184 @default.
• W2136970654 hasConceptScore W2136970654C2777313579 @default.
• W2136970654 hasConceptScore W2136970654C55493867 @default.
• W2136970654 hasConceptScore W2136970654C71924100 @default.
• W2136970654 hasConceptScore W2136970654C86803240 @default.
• W2136970654 hasConceptScore W2136970654C8891405 @default.
• W2136970654 hasIssue "4" @default.
• W2136970654 hasLocation W21369706541 @default.
• W2136970654 hasLocation W21369706542 @default.
• W2136970654 hasLocation W21369706543 @default.
• W2136970654 hasLocation W21369706544 @default.
• W2136970654 hasOpenAccess W2136970654 @default.
• W2136970654 hasPrimaryLocation W21369706541 @default.
• W2136970654 hasRelatedWork W1175477002 @default.
• W2136970654 hasRelatedWork W2016026239 @default.
• W2136970654 hasRelatedWork W2034034393 @default.
• W2136970654 hasRelatedWork W2047284239 @default.
• W2136970654 hasRelatedWork W2141330728 @default.
• W2136970654 hasRelatedWork W2748952813 @default.
• W2136970654 hasRelatedWork W2899084033 @default.
• W2136970654 hasRelatedWork W2950294885 @default.
• W2136970654 hasRelatedWork W2952106524 @default.
• W2136970654 hasRelatedWork W2092574026 @default.

• next