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• W2136986586 abstract "The t-loop structure of mammalian telomeres is thought to repress nonhomologous end joining (NHEJ) at natural chromosome ends. Telomere NHEJ occurs upon loss of TRF2, a telomeric protein implicated in t-loop formation. Here we describe a mutant allele of TRF2, TRF2ΔB, that suppressed NHEJ but induced catastrophic deletions of telomeric DNA. The deletion events were stochastic and occurred rapidly, generating dramatically shortened telomeres that were accompanied by a DNA damage response and induction of senescence. TRF2ΔB-induced deletions depended on XRCC3, a protein implicated in Holliday junction resolution, and created t-loop-sized telomeric circles. These telomeric circles were also detected in unperturbed cells and suggested that t-loop deletion by homologous recombination (HR) might contribute to telomere attrition. Human ALT cells had abundant telomeric circles, pointing to frequent t-loop HR events that could promote rolling circle replication of telomeres in the absence of telomerase. These findings show that t-loop deletion by HR influences the integrity and dynamics of mammalian telomeres." @default.
• W2136986586 created "2016-06-24" @default.
• W2136986586 creator A5038386828 @default.
• W2136986586 creator A5065113600 @default.
• W2136986586 creator A5073054152 @default.
• W2136986586 date "2004-10-01" @default.
• W2136986586 modified "2023-10-16" @default.
• W2136986586 title "Homologous Recombination Generates T-Loop-Sized Deletions at Human Telomeres" @default.
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• W2136986586 cites W1562677361 @default.
• W2136986586 cites W1593021735 @default.
• W2136986586 cites W1700797585 @default.
• W2136986586 cites W1927581912 @default.
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• W2136986586 doi "https://doi.org/10.1016/j.cell.2004.10.011" @default.
• W2136986586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15507207" @default.
• W2136986586 hasPublicationYear "2004" @default.
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