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- W2136987922 abstract "An important role of cell matrix adhesion receptors is to mediate transmembrane coupling between extracellular matrix attachment, actin reorganization, and cell spreading. Thrombospondin (TSP)-1 is a modulatory component of matrix expressed during development, immune response, or wound repair. Cell adhesion to TSP-1 involves formation of biochemically distinct matrix contacts based on stable fascin spikes. The cell surface adhesion receptors required have not been identified. We report here that antibody clustering of syndecan-1 proteoglycan specifically transduces organization of cortical actin and fascin bundles in several cell types. Transfection of COS-7 cells with syndecan-1 is sufficient to stimulate cell spreading, fascin spike assembly, and extensive protrusive lateral ruffling on TSP-1 or on syndecan-1 antibody. The underlying molecular mechanism depends on glycosaminoglycan (GAG) modification of the syndecan-1 core protein at residues S45 or S47 for cell membrane spreading and on the VC2 region of the cytoplasmic domain for spreading and fascin spike formation. Expression of the VC2 deletion mutant or GAG-negative syndecan-1 showed that syndecan-1 is necessary in spreading and fascin spike formation by C2C12 cells on TSP-1. These results establish a novel role for syndecan-1 protein in coupling a physiological matrix ligand to formation of a specific matrix contact structure." @default.
- W2136987922 created "2016-06-24" @default.
- W2136987922 creator A5032349799 @default.
- W2136987922 creator A5041021552 @default.
- W2136987922 creator A5085026769 @default.
- W2136987922 date "2001-03-19" @default.
- W2136987922 modified "2023-10-16" @default.
- W2136987922 title "A Role for Syndecan-1 in Coupling Fascin Spike Formation by Thrombospondin-1" @default.
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- W2136987922 doi "https://doi.org/10.1083/jcb.152.6.1169" @default.
- W2136987922 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2199199" @default.
- W2136987922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11257118" @default.
- W2136987922 hasPublicationYear "2001" @default.
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