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• W2136992136 endingPage "362" @default.
• W2136992136 startingPage "353" @default.
• W2136992136 abstract "We investigated the association between genotypes and haplotypes of the c.-61G>T (rs 1801320) and c.-98G>C (rs 1801321) polymorphisms of the RAD51 gene and the occurrence of keratoconus (KC) and Fuchs endothelial corneal dystrophy (FECD) in dependence on some environmental factors.The polymorphisms were genotyped in peripheral blood lymphocytes of 100 KC and 100 FECD patients as well as 150 controls with PCR-RFLP.The G/T genotype of the c.-61G>T polymorphism was associated with significantly increased frequency occurrence of KC (crude OR 2.99, 95% CI 1.75-5.13). On the other hand, the G/G genotype of this polymorphism was positively correlated with a decreased occurrence of this disease (crude OR 0.52, 95% CI 0.31-0.88). We did not find any correlation between genotypes/alleles of the c.-98G>C polymorphism and the occurrence of KC. We also found that the G/G genotype and G allele of the c.-98G>C polymorphism had a protective effect against FECD (crude OR 0.51, 95% CI 0.28-0.92; crude OR 0.53, 95% CI 0.30-0.92, resp.), while the G/C genotype and the C allele increased FECD occurrence (crude OR 1.85, 95% CI 1.01-3.36; crude OR 1.90, 95% CI 1.09-3.29, resp.).The c.-61T/T and c.-98G>C polymorphisms of the RAD51 gene may have a role in the KC and FECD pathogenesis and can be considered as markers in these diseases." @default.
• W2136992136 created "2016-06-24" @default.
• W2136992136 creator A5009465959 @default.
• W2136992136 creator A5032094148 @default.
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• W2136992136 creator A5052186294 @default.
• W2136992136 creator A5067717800 @default.
• W2136992136 creator A5072974035 @default.
• W2136992136 date "2013-01-01" @default.
• W2136992136 modified "2023-10-18" @default.
• W2136992136 title "Polymorphisms of the Homologous Recombination Gene<i>RAD51</i>in Keratoconus and Fuchs Endothelial Corneal Dystrophy" @default.
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