Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137016822> ?p ?o ?g. }
- W2137016822 endingPage "1254" @default.
- W2137016822 startingPage "1245" @default.
- W2137016822 abstract "In the central nervous system (CNS), myelination of axons occurs when oligodendrocyte progenitor cells undergo terminal differentiation, and initiate process formation and axonal ensheathment. Although Fyn, a member of the Src-family kinases (SFKs), plays an important role in this differentiation process, the substrates of Fyn in oligodendrocytes are largely unknown. Using mass spectrometric analysis, we identified focal adhesion kinase (FAK) as a tyrosine-phosphorylated protein in the rat-derived CG4 oligodendrocyte cell line. Tyrosine phosphorylation of FAK was enhanced during differentiation of CG4 cells in a Fyn-dependent manner. In addition, phosphorylation of FAK was stimulated by laminin, one of the ligands for integrin. Knockdown of FAK expression in CG4 cells suppressed process outgrowth on laminin. Rac1 and Cdc42 activities, which are required for oligodendrocyte process formation, were down-regulated in FAK-knockdown cells. Expression of wild-type (WT) FAK in FAK-knockdown CG4 cells restored outgrowth of processes, but the Y397F mutant lacking the autophosphorylation site did not. These results suggest that FAK/Fyn-mediated activation of Rac1 and Cdc42 is critical for laminin-induced outgrowth of oligodendrocyte processes." @default.
- W2137016822 created "2016-06-24" @default.
- W2137016822 creator A5022594173 @default.
- W2137016822 creator A5024136589 @default.
- W2137016822 creator A5045077292 @default.
- W2137016822 creator A5057500761 @default.
- W2137016822 creator A5078386276 @default.
- W2137016822 creator A5086807527 @default.
- W2137016822 date "2007-11-01" @default.
- W2137016822 modified "2023-09-30" @default.
- W2137016822 title "Focal adhesion kinase regulates laminin-induced oligodendroglial process outgrowth" @default.
- W2137016822 cites W1539145460 @default.
- W2137016822 cites W1577573926 @default.
- W2137016822 cites W1608914198 @default.
- W2137016822 cites W1956645860 @default.
- W2137016822 cites W1969821478 @default.
- W2137016822 cites W1973005263 @default.
- W2137016822 cites W1974973994 @default.
- W2137016822 cites W1976828312 @default.
- W2137016822 cites W1977656622 @default.
- W2137016822 cites W1978254752 @default.
- W2137016822 cites W1992569472 @default.
- W2137016822 cites W1994651714 @default.
- W2137016822 cites W1995402199 @default.
- W2137016822 cites W1996131663 @default.
- W2137016822 cites W2010840318 @default.
- W2137016822 cites W2013592169 @default.
- W2137016822 cites W2015602829 @default.
- W2137016822 cites W2023675574 @default.
- W2137016822 cites W2028691987 @default.
- W2137016822 cites W2031733803 @default.
- W2137016822 cites W2042270905 @default.
- W2137016822 cites W2044132589 @default.
- W2137016822 cites W2044895919 @default.
- W2137016822 cites W2049360086 @default.
- W2137016822 cites W2062527576 @default.
- W2137016822 cites W2062552161 @default.
- W2137016822 cites W2063306294 @default.
- W2137016822 cites W2080467864 @default.
- W2137016822 cites W2083881671 @default.
- W2137016822 cites W2085082236 @default.
- W2137016822 cites W2088591814 @default.
- W2137016822 cites W2089075706 @default.
- W2137016822 cites W2104075420 @default.
- W2137016822 cites W2105356859 @default.
- W2137016822 cites W2109357648 @default.
- W2137016822 cites W2115136264 @default.
- W2137016822 cites W2121645463 @default.
- W2137016822 cites W2128979512 @default.
- W2137016822 cites W2134629457 @default.
- W2137016822 cites W2166742757 @default.
- W2137016822 doi "https://doi.org/10.1111/j.1365-2443.2007.01130.x" @default.
- W2137016822 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17986008" @default.
- W2137016822 hasPublicationYear "2007" @default.
- W2137016822 type Work @default.
- W2137016822 sameAs 2137016822 @default.
- W2137016822 citedByCount "37" @default.
- W2137016822 countsByYear W21370168222012 @default.
- W2137016822 countsByYear W21370168222013 @default.
- W2137016822 countsByYear W21370168222014 @default.
- W2137016822 countsByYear W21370168222015 @default.
- W2137016822 countsByYear W21370168222016 @default.
- W2137016822 countsByYear W21370168222017 @default.
- W2137016822 countsByYear W21370168222018 @default.
- W2137016822 countsByYear W21370168222019 @default.
- W2137016822 countsByYear W21370168222021 @default.
- W2137016822 countsByYear W21370168222022 @default.
- W2137016822 countsByYear W21370168222023 @default.
- W2137016822 crossrefType "journal-article" @default.
- W2137016822 hasAuthorship W2137016822A5022594173 @default.
- W2137016822 hasAuthorship W2137016822A5024136589 @default.
- W2137016822 hasAuthorship W2137016822A5045077292 @default.
- W2137016822 hasAuthorship W2137016822A5057500761 @default.
- W2137016822 hasAuthorship W2137016822A5078386276 @default.
- W2137016822 hasAuthorship W2137016822A5086807527 @default.
- W2137016822 hasBestOaLocation W21370168221 @default.
- W2137016822 hasConcept C108391706 @default.
- W2137016822 hasConcept C108636557 @default.
- W2137016822 hasConcept C11960822 @default.
- W2137016822 hasConcept C150109051 @default.
- W2137016822 hasConcept C151166631 @default.
- W2137016822 hasConcept C169760540 @default.
- W2137016822 hasConcept C2776985911 @default.
- W2137016822 hasConcept C2777553839 @default.
- W2137016822 hasConcept C2778609137 @default.
- W2137016822 hasConcept C37686147 @default.
- W2137016822 hasConcept C529278444 @default.
- W2137016822 hasConcept C86803240 @default.
- W2137016822 hasConcept C90934575 @default.
- W2137016822 hasConcept C95444343 @default.
- W2137016822 hasConcept C97029542 @default.
- W2137016822 hasConceptScore W2137016822C108391706 @default.
- W2137016822 hasConceptScore W2137016822C108636557 @default.
- W2137016822 hasConceptScore W2137016822C11960822 @default.
- W2137016822 hasConceptScore W2137016822C150109051 @default.
- W2137016822 hasConceptScore W2137016822C151166631 @default.
- W2137016822 hasConceptScore W2137016822C169760540 @default.
- W2137016822 hasConceptScore W2137016822C2776985911 @default.