Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137034443> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2137034443 endingPage "883" @default.
- W2137034443 startingPage "879" @default.
- W2137034443 abstract "Free immunoglobulin light chains (FLCs) have previously been shown to be uraemic toxins. In this work we investigated the effect of haemodialysis and haemodiafiltration on the level of FLCs in serum/plasma of uraemic patients.Serum/plasma proteins were separated by non-reducing SDS-PAGE and transferred to a nitro-cellulose membrane. FLCs were detected by specific antibodies and an enhanced chemiluminescence detection system. The FLC concentrations were calculated. We studied 15 healthy subjects, 10 patients with chronic renal failure, 71 patients undergoing haemodialysis treatment and 33 patients treated with haemodiafiltration. Different membranes were compared: low- and high-flux polysulfone membranes, low- and high-flux cellulose triacetate membranes, high-flux polymethylmethacrylate and polyacrylonitrile membranes.Chronic renal failure patients showed elevated FLC concentrations as compared with controls. In haemodialysis or haemodiafiltration patients these values were even higher. This was mainly due to an increased concentration of FLC of the lambda-type. The treatment modality per se did not influence the FLC concentrations. Only haemodialysis or haemodiafiltration with the polymethylmethacrylate membrane lead to a significant reduction in FLC concentrations; however, these did not reach control levels. We did not observe differences in FLC levels between patients with different underlying diseases, nor did we find a correlation between age or the duration of the dialysis treatment and FLC concentrations. We found a positive correlation between FLC concentrations at the beginning of dialysis treatment and the amount of IgLCs removed during treatment. However, the average FLC level after treatment did not reach control values.Currently available haemodialysis or haemodiafiltration treatments are unable to normalize the elevated serum/plasma levels of FLCs in end-stage renal disease patients." @default.
- W2137034443 created "2016-06-24" @default.
- W2137034443 creator A5007789795 @default.
- W2137034443 creator A5038954546 @default.
- W2137034443 creator A5050993682 @default.
- W2137034443 creator A5091560797 @default.
- W2137034443 date "2002-05-01" @default.
- W2137034443 modified "2023-09-23" @default.
- W2137034443 title "Effect of dialysis on serum/plasma levels of free immunoglobulin light chains in end-stage renal disease patients" @default.
- W2137034443 cites W1498806091 @default.
- W2137034443 cites W1582360474 @default.
- W2137034443 cites W1978670350 @default.
- W2137034443 cites W1989219157 @default.
- W2137034443 cites W2025353040 @default.
- W2137034443 cites W2072139461 @default.
- W2137034443 cites W2082622199 @default.
- W2137034443 cites W2090800579 @default.
- W2137034443 cites W2144341929 @default.
- W2137034443 cites W2399756667 @default.
- W2137034443 cites W2417814069 @default.
- W2137034443 cites W2467825266 @default.
- W2137034443 doi "https://doi.org/10.1093/ndt/17.5.879" @default.
- W2137034443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11981077" @default.
- W2137034443 hasPublicationYear "2002" @default.
- W2137034443 type Work @default.
- W2137034443 sameAs 2137034443 @default.
- W2137034443 citedByCount "46" @default.
- W2137034443 countsByYear W21370344432012 @default.
- W2137034443 countsByYear W21370344432013 @default.
- W2137034443 countsByYear W21370344432014 @default.
- W2137034443 countsByYear W21370344432015 @default.
- W2137034443 countsByYear W21370344432016 @default.
- W2137034443 countsByYear W21370344432017 @default.
- W2137034443 countsByYear W21370344432018 @default.
- W2137034443 countsByYear W21370344432019 @default.
- W2137034443 countsByYear W21370344432020 @default.
- W2137034443 countsByYear W21370344432022 @default.
- W2137034443 countsByYear W21370344432023 @default.
- W2137034443 crossrefType "journal-article" @default.
- W2137034443 hasAuthorship W2137034443A5007789795 @default.
- W2137034443 hasAuthorship W2137034443A5038954546 @default.
- W2137034443 hasAuthorship W2137034443A5050993682 @default.
- W2137034443 hasAuthorship W2137034443A5091560797 @default.
- W2137034443 hasBestOaLocation W21370344431 @default.
- W2137034443 hasConcept C126322002 @default.
- W2137034443 hasConcept C126894567 @default.
- W2137034443 hasConcept C134018914 @default.
- W2137034443 hasConcept C159654299 @default.
- W2137034443 hasConcept C185592680 @default.
- W2137034443 hasConcept C203014093 @default.
- W2137034443 hasConcept C2775863688 @default.
- W2137034443 hasConcept C2778063415 @default.
- W2137034443 hasConcept C2778653478 @default.
- W2137034443 hasConcept C2779978075 @default.
- W2137034443 hasConcept C41625074 @default.
- W2137034443 hasConcept C43617362 @default.
- W2137034443 hasConcept C55493867 @default.
- W2137034443 hasConcept C71924100 @default.
- W2137034443 hasConcept C90924648 @default.
- W2137034443 hasConceptScore W2137034443C126322002 @default.
- W2137034443 hasConceptScore W2137034443C126894567 @default.
- W2137034443 hasConceptScore W2137034443C134018914 @default.
- W2137034443 hasConceptScore W2137034443C159654299 @default.
- W2137034443 hasConceptScore W2137034443C185592680 @default.
- W2137034443 hasConceptScore W2137034443C203014093 @default.
- W2137034443 hasConceptScore W2137034443C2775863688 @default.
- W2137034443 hasConceptScore W2137034443C2778063415 @default.
- W2137034443 hasConceptScore W2137034443C2778653478 @default.
- W2137034443 hasConceptScore W2137034443C2779978075 @default.
- W2137034443 hasConceptScore W2137034443C41625074 @default.
- W2137034443 hasConceptScore W2137034443C43617362 @default.
- W2137034443 hasConceptScore W2137034443C55493867 @default.
- W2137034443 hasConceptScore W2137034443C71924100 @default.
- W2137034443 hasConceptScore W2137034443C90924648 @default.
- W2137034443 hasIssue "5" @default.
- W2137034443 hasLocation W21370344431 @default.
- W2137034443 hasLocation W21370344432 @default.
- W2137034443 hasOpenAccess W2137034443 @default.
- W2137034443 hasPrimaryLocation W21370344431 @default.
- W2137034443 hasRelatedWork W1514131650 @default.
- W2137034443 hasRelatedWork W1979139803 @default.
- W2137034443 hasRelatedWork W1999890744 @default.
- W2137034443 hasRelatedWork W2016035041 @default.
- W2137034443 hasRelatedWork W2131816968 @default.
- W2137034443 hasRelatedWork W2138956445 @default.
- W2137034443 hasRelatedWork W2746183029 @default.
- W2137034443 hasRelatedWork W2748952813 @default.
- W2137034443 hasRelatedWork W4254775923 @default.
- W2137034443 hasRelatedWork W4383709113 @default.
- W2137034443 hasVolume "17" @default.
- W2137034443 isParatext "false" @default.
- W2137034443 isRetracted "false" @default.
- W2137034443 magId "2137034443" @default.
- W2137034443 workType "article" @default.