Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137048874> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2137048874 abstract "Control analysis can be used to try to understand why (quantitatively) systems are the way that they are, from rate constants within proteins to the relative amount of different tissues in organisms. Many biological parameters appear to be optimized to maximize rates under the constraint of minimizing space utilization. For any biological process with multiple steps that compete for control in series, evolution by natural selection will tend to even out the control exerted by each step. This is for two reasons: (i) shared control maximizes the flux for minimum protein concentration, and (ii) the selection pressure on any step is proportional to its control, and selection will, by increasing the rate of a step (relative to other steps), decrease its control over a pathway. The control coefficient of a parameter P over fitness can be defined as (∂N/N)/(∂P/P), where N is the number of individuals in the population, and ∂N is the change in that number as a result of the change in P. This control coefficient is equal to the selection pressure on P. I argue that biological systems optimized by natural selection will conform to a principle of sufficiency, such that the control coefficient of all parameters over fitness is 0. Thus in an optimized system small changes in parameters will have a negligible effect on fitness. This principle naturally leads to (and is supported by) the dominance of wild-type alleles over null mutants." @default.
- W2137048874 created "2016-06-24" @default.
- W2137048874 creator A5042066616 @default.
- W2137048874 date "2010-09-24" @default.
- W2137048874 modified "2023-09-26" @default.
- W2137048874 title "The principle of sufficiency and the evolution of control: using control analysis to understand the design principles of biological systems" @default.
- W2137048874 cites W1606784130 @default.
- W2137048874 cites W172910503 @default.
- W2137048874 cites W1864895841 @default.
- W2137048874 cites W2009166480 @default.
- W2137048874 cites W2016528906 @default.
- W2137048874 cites W2020616105 @default.
- W2137048874 cites W2026564977 @default.
- W2137048874 cites W2059617446 @default.
- W2137048874 cites W2066261007 @default.
- W2137048874 cites W2066363086 @default.
- W2137048874 cites W2082672923 @default.
- W2137048874 cites W2112752425 @default.
- W2137048874 cites W2126582986 @default.
- W2137048874 cites W2135544482 @default.
- W2137048874 cites W2157829264 @default.
- W2137048874 cites W2336670847 @default.
- W2137048874 doi "https://doi.org/10.1042/bst0381210" @default.
- W2137048874 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20863286" @default.
- W2137048874 hasPublicationYear "2010" @default.
- W2137048874 type Work @default.
- W2137048874 sameAs 2137048874 @default.
- W2137048874 citedByCount "3" @default.
- W2137048874 countsByYear W21370488742014 @default.
- W2137048874 countsByYear W21370488742015 @default.
- W2137048874 crossrefType "journal-article" @default.
- W2137048874 hasAuthorship W2137048874A5042066616 @default.
- W2137048874 hasConcept C105795698 @default.
- W2137048874 hasConcept C111919701 @default.
- W2137048874 hasConcept C144024400 @default.
- W2137048874 hasConcept C149923435 @default.
- W2137048874 hasConcept C154945302 @default.
- W2137048874 hasConcept C2524010 @default.
- W2137048874 hasConcept C2775924081 @default.
- W2137048874 hasConcept C2776036281 @default.
- W2137048874 hasConcept C2908647359 @default.
- W2137048874 hasConcept C33923547 @default.
- W2137048874 hasConcept C41008148 @default.
- W2137048874 hasConcept C47446073 @default.
- W2137048874 hasConcept C75268714 @default.
- W2137048874 hasConcept C81917197 @default.
- W2137048874 hasConcept C98045186 @default.
- W2137048874 hasConceptScore W2137048874C105795698 @default.
- W2137048874 hasConceptScore W2137048874C111919701 @default.
- W2137048874 hasConceptScore W2137048874C144024400 @default.
- W2137048874 hasConceptScore W2137048874C149923435 @default.
- W2137048874 hasConceptScore W2137048874C154945302 @default.
- W2137048874 hasConceptScore W2137048874C2524010 @default.
- W2137048874 hasConceptScore W2137048874C2775924081 @default.
- W2137048874 hasConceptScore W2137048874C2776036281 @default.
- W2137048874 hasConceptScore W2137048874C2908647359 @default.
- W2137048874 hasConceptScore W2137048874C33923547 @default.
- W2137048874 hasConceptScore W2137048874C41008148 @default.
- W2137048874 hasConceptScore W2137048874C47446073 @default.
- W2137048874 hasConceptScore W2137048874C75268714 @default.
- W2137048874 hasConceptScore W2137048874C81917197 @default.
- W2137048874 hasConceptScore W2137048874C98045186 @default.
- W2137048874 hasLocation W21370488741 @default.
- W2137048874 hasLocation W21370488742 @default.
- W2137048874 hasOpenAccess W2137048874 @default.
- W2137048874 hasPrimaryLocation W21370488741 @default.
- W2137048874 hasRelatedWork W1592513025 @default.
- W2137048874 hasRelatedWork W182376415 @default.
- W2137048874 hasRelatedWork W1966403594 @default.
- W2137048874 hasRelatedWork W1981124759 @default.
- W2137048874 hasRelatedWork W1993351707 @default.
- W2137048874 hasRelatedWork W1995441474 @default.
- W2137048874 hasRelatedWork W1999657361 @default.
- W2137048874 hasRelatedWork W2001899340 @default.
- W2137048874 hasRelatedWork W2025507498 @default.
- W2137048874 hasRelatedWork W2030215424 @default.
- W2137048874 hasRelatedWork W2043938372 @default.
- W2137048874 hasRelatedWork W2059576172 @default.
- W2137048874 hasRelatedWork W2077190367 @default.
- W2137048874 hasRelatedWork W2088151813 @default.
- W2137048874 hasRelatedWork W2198928891 @default.
- W2137048874 hasRelatedWork W2316343985 @default.
- W2137048874 hasRelatedWork W2606887236 @default.
- W2137048874 hasRelatedWork W2907231283 @default.
- W2137048874 hasRelatedWork W3101156351 @default.
- W2137048874 hasRelatedWork W3199637462 @default.
- W2137048874 isParatext "false" @default.
- W2137048874 isRetracted "false" @default.
- W2137048874 magId "2137048874" @default.
- W2137048874 workType "article" @default.