FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137052570> ?p ?o ?g. }

• W2137052570 endingPage "624" @default.
• W2137052570 startingPage "622" @default.
• W2137052570 abstract "Annexin 6 is one of a widely expressed family of calcium-binding proteins found in most mammalian tissues, including the heart. Several studies have implicated annexin 6 in the regulation of intracellular Ca2+ signaling, and it has been shown in vitro to act as a modulator of the sarcoplasmic reticulum Ca2+-release channel, cardiac L-type calcium channel, and Na+/Ca2+ exchanger. To investigate the role of annexin 6 in intact cardiomyocytes, we used mice containing a targeted disruption of the annexin 6 gene. Compared with controls, the myocytes of annexin 6 null-mutant mice demonstrated a significant increase in the rates of shortening and relengthening. Intracellular Ca2+ transients in fura-2-loaded cardiomyocytes induced by caffeine showed a normal baseline and amplitude, whereas the rate of decay was doubled in annexin 6-/- myocytes compared with control mice. These results show that annexin 6 knockout in the mouse leads to an increase in myocyte contractility and faster diastolic Ca2+ removal from the cytoplasm. In light of published findings showing annexin 6 to be down-regulated in end-stage heart failure, these results are consistent with a role for annexin 6 as a negative inotropic factor in the regulation of cardiomyocyte mechanics." @default.
• W2137052570 created "2016-06-24" @default.
• W2137052570 creator A5007479397 @default.
• W2137052570 creator A5008156063 @default.
• W2137052570 creator A5008534300 @default.
• W2137052570 creator A5018410798 @default.
• W2137052570 creator A5055266997 @default.
• W2137052570 creator A5064124303 @default.
• W2137052570 creator A5068986246 @default.
• W2137052570 date "2002-02-12" @default.
• W2137052570 modified "2023-10-16" @default.
• W2137052570 title "Altered mechanical properties and intracellular calcium signaling in cardiomyocytes from annexin 6 null‐mutant mice" @default.
• W2137052570 cites W1540596982 @default.
• W2137052570 cites W1610924477 @default.
• W2137052570 cites W1792891338 @default.
• W2137052570 cites W1915414624 @default.
• W2137052570 cites W1971229190 @default.
• W2137052570 cites W1976301405 @default.
• W2137052570 cites W1983604682 @default.
• W2137052570 cites W1988183722 @default.
• W2137052570 cites W1992400924 @default.
• W2137052570 cites W1992756005 @default.
• W2137052570 cites W2016201436 @default.
• W2137052570 cites W2034272768 @default.
• W2137052570 cites W2070314562 @default.
• W2137052570 cites W2075775838 @default.
• W2137052570 cites W2079774792 @default.
• W2137052570 cites W2098707091 @default.
• W2137052570 cites W2103670573 @default.
• W2137052570 cites W2131082171 @default.
• W2137052570 cites W2160272259 @default.
• W2137052570 cites W2161963254 @default.
• W2137052570 cites W2167597644 @default.
• W2137052570 cites W2402260870 @default.
• W2137052570 cites W2464929825 @default.
• W2137052570 doi "https://doi.org/10.1096/fj.01-0892fje" @default.
• W2137052570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11919174" @default.
• W2137052570 hasPublicationYear "2002" @default.
• W2137052570 type Work @default.
• W2137052570 sameAs 2137052570 @default.
• W2137052570 citedByCount "55" @default.
• W2137052570 countsByYear W21370525702012 @default.
• W2137052570 countsByYear W21370525702013 @default.
• W2137052570 countsByYear W21370525702014 @default.
• W2137052570 countsByYear W21370525702015 @default.
• W2137052570 countsByYear W21370525702016 @default.
• W2137052570 countsByYear W21370525702017 @default.
• W2137052570 countsByYear W21370525702018 @default.
• W2137052570 countsByYear W21370525702019 @default.
• W2137052570 countsByYear W21370525702020 @default.
• W2137052570 countsByYear W21370525702021 @default.
• W2137052570 countsByYear W21370525702022 @default.
• W2137052570 crossrefType "journal-article" @default.
• W2137052570 hasAuthorship W2137052570A5007479397 @default.
• W2137052570 hasAuthorship W2137052570A5008156063 @default.
• W2137052570 hasAuthorship W2137052570A5008534300 @default.
• W2137052570 hasAuthorship W2137052570A5018410798 @default.
• W2137052570 hasAuthorship W2137052570A5055266997 @default.
• W2137052570 hasAuthorship W2137052570A5064124303 @default.
• W2137052570 hasAuthorship W2137052570A5068986246 @default.
• W2137052570 hasConcept C126322002 @default.
• W2137052570 hasConcept C134018914 @default.
• W2137052570 hasConcept C153911025 @default.
• W2137052570 hasConcept C158617107 @default.
• W2137052570 hasConcept C181080969 @default.
• W2137052570 hasConcept C185592680 @default.
• W2137052570 hasConcept C190283241 @default.
• W2137052570 hasConcept C201571599 @default.
• W2137052570 hasConcept C207200792 @default.
• W2137052570 hasConcept C30345302 @default.
• W2137052570 hasConcept C519063684 @default.
• W2137052570 hasConcept C55493867 @default.
• W2137052570 hasConcept C71924100 @default.
• W2137052570 hasConcept C79879829 @default.
• W2137052570 hasConcept C86803240 @default.
• W2137052570 hasConcept C88634738 @default.
• W2137052570 hasConcept C95444343 @default.
• W2137052570 hasConceptScore W2137052570C126322002 @default.
• W2137052570 hasConceptScore W2137052570C134018914 @default.
• W2137052570 hasConceptScore W2137052570C153911025 @default.
• W2137052570 hasConceptScore W2137052570C158617107 @default.
• W2137052570 hasConceptScore W2137052570C181080969 @default.
• W2137052570 hasConceptScore W2137052570C185592680 @default.
• W2137052570 hasConceptScore W2137052570C190283241 @default.
• W2137052570 hasConceptScore W2137052570C201571599 @default.
• W2137052570 hasConceptScore W2137052570C207200792 @default.
• W2137052570 hasConceptScore W2137052570C30345302 @default.
• W2137052570 hasConceptScore W2137052570C519063684 @default.
• W2137052570 hasConceptScore W2137052570C55493867 @default.
• W2137052570 hasConceptScore W2137052570C71924100 @default.
• W2137052570 hasConceptScore W2137052570C79879829 @default.
• W2137052570 hasConceptScore W2137052570C86803240 @default.
• W2137052570 hasConceptScore W2137052570C88634738 @default.
• W2137052570 hasConceptScore W2137052570C95444343 @default.
• W2137052570 hasFunder F4320319992 @default.
• W2137052570 hasIssue "6" @default.
• W2137052570 hasLocation W21370525701 @default.
• W2137052570 hasLocation W21370525702 @default.

• next