FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137079077> ?p ?o ?g. }

• W2137079077 endingPage "e12361" @default.
• W2137079077 startingPage "e12361" @default.
• W2137079077 abstract "Changes in lifestyle have resulted in an epidemic development of obesity-related diseases that challenge the healthcare systems worldwide. To develop strategies to tackle this problem the focus is on diet to prevent the development of obesity-associated diseases such as cardiovascular disease (CVD). This will require methods for linking nutrient intake with specific metabolic processes in different tissues.Low-density lipoprotein receptor-deficient (Ldlr -/-) mice were fed a high fat/high sugar diet to mimic a westernized diet, being a major reason for development of obesity and atherosclerosis. The diets were supplemented with either beef or herring, and matched in macronutrient contents. Body composition, plasma lipids and aortic lesion areas were measured. Transcriptomes of metabolically important tissues, e.g. liver, muscle and adipose tissue were analyzed by an integrated approach with metabolic networks to directly map the metabolic effects of diet in these different tissues. Our analysis revealed a reduction in sterol metabolism and protein turnover at the transcriptional level in herring-fed mice.This study shows that an integrated analysis of transcriptome data using metabolic networks resulted in the identification of signature pathways. This could not have been achieved using standard clustering methods. In particular, this systems biology analysis could enrich the information content of biomedical or nutritional data where subtle changes in several tissues together affects body metabolism or disease progression. This could be applied to improve diets for subjects exposed to health risks associated with obesity." @default.
• W2137079077 created "2016-06-24" @default.
• W2137079077 creator A5008739880 @default.
• W2137079077 creator A5032814858 @default.
• W2137079077 creator A5038266891 @default.
• W2137079077 creator A5071907882 @default.
• W2137079077 creator A5083238115 @default.
• W2137079077 date "2010-08-24" @default.
• W2137079077 modified "2023-10-17" @default.
• W2137079077 title "Identifying Molecular Effects of Diet through Systems Biology: Influence of Herring Diet on Sterol Metabolism and Protein Turnover in Mice" @default.
• W2137079077 cites W1565311713 @default.
• W2137079077 cites W1754711307 @default.
• W2137079077 cites W1875232251 @default.
• W2137079077 cites W1944450372 @default.
• W2137079077 cites W1963916955 @default.
• W2137079077 cites W1979240894 @default.
• W2137079077 cites W1988649393 @default.
• W2137079077 cites W2008254763 @default.
• W2137079077 cites W2008294451 @default.
• W2137079077 cites W2013785254 @default.
• W2137079077 cites W2028561804 @default.
• W2137079077 cites W2030028650 @default.
• W2137079077 cites W2031595603 @default.
• W2137079077 cites W2033211134 @default.
• W2137079077 cites W2038563918 @default.
• W2137079077 cites W2041717886 @default.
• W2137079077 cites W2053765200 @default.
• W2137079077 cites W2060507377 @default.
• W2137079077 cites W2066573647 @default.
• W2137079077 cites W2086429724 @default.
• W2137079077 cites W2086453930 @default.
• W2137079077 cites W2087706636 @default.
• W2137079077 cites W2100712027 @default.
• W2137079077 cites W2102563922 @default.
• W2137079077 cites W2103017472 @default.
• W2137079077 cites W2109326254 @default.
• W2137079077 cites W2128264631 @default.
• W2137079077 cites W2132365435 @default.
• W2137079077 cites W2132992030 @default.
• W2137079077 cites W2139608294 @default.
• W2137079077 cites W2143643296 @default.
• W2137079077 cites W2148930194 @default.
• W2137079077 cites W2153142198 @default.
• W2137079077 cites W2154061034 @default.
• W2137079077 cites W2154587590 @default.
• W2137079077 cites W2159675211 @default.
• W2137079077 cites W2160681814 @default.
• W2137079077 cites W2162931673 @default.
• W2137079077 cites W2167911266 @default.
• W2137079077 cites W2169589032 @default.
• W2137079077 cites W2170989872 @default.
• W2137079077 cites W32010000 @default.
• W2137079077 doi "https://doi.org/10.1371/journal.pone.0012361" @default.
• W2137079077 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2927425" @default.
• W2137079077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20808764" @default.
• W2137079077 hasPublicationYear "2010" @default.
• W2137079077 type Work @default.
• W2137079077 sameAs 2137079077 @default.
• W2137079077 citedByCount "19" @default.
• W2137079077 countsByYear W21370790772012 @default.
• W2137079077 countsByYear W21370790772013 @default.
• W2137079077 countsByYear W21370790772015 @default.
• W2137079077 countsByYear W21370790772016 @default.
• W2137079077 countsByYear W21370790772017 @default.
• W2137079077 countsByYear W21370790772021 @default.
• W2137079077 crossrefType "journal-article" @default.
• W2137079077 hasAuthorship W2137079077A5008739880 @default.
• W2137079077 hasAuthorship W2137079077A5032814858 @default.
• W2137079077 hasAuthorship W2137079077A5038266891 @default.
• W2137079077 hasAuthorship W2137079077A5071907882 @default.
• W2137079077 hasAuthorship W2137079077A5083238115 @default.
• W2137079077 hasBestOaLocation W21370790771 @default.
• W2137079077 hasConcept C104317684 @default.
• W2137079077 hasConcept C126322002 @default.
• W2137079077 hasConcept C134018914 @default.
• W2137079077 hasConcept C150194340 @default.
• W2137079077 hasConcept C162317418 @default.
• W2137079077 hasConcept C171089720 @default.
• W2137079077 hasConcept C42407357 @default.
• W2137079077 hasConcept C4733338 @default.
• W2137079077 hasConcept C511355011 @default.
• W2137079077 hasConcept C55493867 @default.
• W2137079077 hasConcept C60644358 @default.
• W2137079077 hasConcept C62231903 @default.
• W2137079077 hasConcept C71924100 @default.
• W2137079077 hasConcept C86803240 @default.
• W2137079077 hasConceptScore W2137079077C104317684 @default.
• W2137079077 hasConceptScore W2137079077C126322002 @default.
• W2137079077 hasConceptScore W2137079077C134018914 @default.
• W2137079077 hasConceptScore W2137079077C150194340 @default.
• W2137079077 hasConceptScore W2137079077C162317418 @default.
• W2137079077 hasConceptScore W2137079077C171089720 @default.
• W2137079077 hasConceptScore W2137079077C42407357 @default.
• W2137079077 hasConceptScore W2137079077C4733338 @default.
• W2137079077 hasConceptScore W2137079077C511355011 @default.
• W2137079077 hasConceptScore W2137079077C55493867 @default.
• W2137079077 hasConceptScore W2137079077C60644358 @default.
• W2137079077 hasConceptScore W2137079077C62231903 @default.

• next