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• W2137084055 abstract "Phosphatidylinositol (PI) 3,4-P(2) is a phosphoinositide that has been shown to be important for signal transduction in growth factor stimulation. We have produced monoclonal antibodies specific for PI 3,4-P(2), which were able to detect PI 3,4-P(2) generated in 293T cells treated with H(2)O(2), or in MKN45/BD110 cells expressing activated PI 3-kinase in immunostaining. Prolonged treatment with 0.05% Tween 20 resulted in detection of staining not only at the plasma membrane, but also at the nuclear surface, indicating that 3'-phosphorylated phosphoinositides can be generated and function in the nucleus." @default.
• W2137084055 created "2016-06-24" @default.
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• W2137084055 date "2000-05-09" @default.
• W2137084055 modified "2023-09-30" @default.
• W2137084055 title "Evidence that 3′-phosphorylated polyphosphoinositides are generated at the nuclear surface: use of immunostaining technique with monoclonal antibodies specific for PI 3,4-P₂" @default.
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• W2137084055 doi "https://doi.org/10.1016/s0014-5793(00)01535-0" @default.
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