Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137087433> ?p ?o ?g. }
- W2137087433 endingPage "4746" @default.
- W2137087433 startingPage "4746" @default.
- W2137087433 abstract "Copper is known to be a critical factor in Alzheimer's disease (AD) pathogenesis, as it is involved in amyloid-β (Aβ) peptide related toxicity. However, the relationship between neurotoxicity and Aβ peptide in the presence of copper remains unclear. The effect of copper has not been clearly differentiated between Aβ42 and Aβ40, and it is still debated whether copper-mediated neurotoxicity is due to reactive oxygen species (ROS) accumulation or other molecular mechanisms. Here, we describe that copper dramatically affects Aβ42 aggregation and enhances Aβ42 cytotoxicity while it shows no significant effects on Aβ40. These phenomena are mainly because that the strong interactions between copper and Aβ42 lead to great conformation changes, and stabilize Aβ42 aggregates at highly toxic nanoscale oligomer stage, whereas copper shows no similar impact on Aβ40. We also propose a possible molecular mechanism that copper enhances Aβ42 cytotoxicity via perturbing membrane structure. Moreover, we test the effect of an analogue of copper, nickel, on Aβ aggregation and cytotoxicity, finding that nickel also enhances cytotoxicity via Aβ42 nanoscale oligomer formation. These results clarify that the copper-induced Aβ42 nanoscale oligomer formation is the key process for Aβ neurotoxicity, and suggest that disrupting the interactions between copper and Aβ42 peptide to inhibit nanoscale oligomerization process, deserves more attention in AD drug development." @default.
- W2137087433 created "2016-06-24" @default.
- W2137087433 creator A5021449466 @default.
- W2137087433 creator A5027066046 @default.
- W2137087433 creator A5031398448 @default.
- W2137087433 creator A5040817099 @default.
- W2137087433 creator A5085898674 @default.
- W2137087433 date "2011-01-01" @default.
- W2137087433 modified "2023-09-25" @default.
- W2137087433 title "Copper inducing Aβ42 rather than Aβ40 nanoscale oligomer formation is the key process for Aβ neurotoxicity" @default.
- W2137087433 cites W1529315529 @default.
- W2137087433 cites W1538720707 @default.
- W2137087433 cites W1545803103 @default.
- W2137087433 cites W1677883125 @default.
- W2137087433 cites W1707143272 @default.
- W2137087433 cites W1960543132 @default.
- W2137087433 cites W1963868764 @default.
- W2137087433 cites W1980357013 @default.
- W2137087433 cites W1980906872 @default.
- W2137087433 cites W1985891852 @default.
- W2137087433 cites W1996579240 @default.
- W2137087433 cites W2018333394 @default.
- W2137087433 cites W2042897050 @default.
- W2137087433 cites W2046847750 @default.
- W2137087433 cites W2050369906 @default.
- W2137087433 cites W2055659156 @default.
- W2137087433 cites W2062438517 @default.
- W2137087433 cites W2067214887 @default.
- W2137087433 cites W2071953900 @default.
- W2137087433 cites W2075481535 @default.
- W2137087433 cites W2077235062 @default.
- W2137087433 cites W2081099437 @default.
- W2137087433 cites W2081182167 @default.
- W2137087433 cites W2083500052 @default.
- W2137087433 cites W2086142786 @default.
- W2137087433 cites W2090718260 @default.
- W2137087433 cites W2093399444 @default.
- W2137087433 cites W2097965815 @default.
- W2137087433 cites W2113472155 @default.
- W2137087433 cites W2122294662 @default.
- W2137087433 cites W2126964809 @default.
- W2137087433 cites W2131633241 @default.
- W2137087433 cites W2134909516 @default.
- W2137087433 cites W2138417832 @default.
- W2137087433 cites W2152058429 @default.
- W2137087433 cites W2159237576 @default.
- W2137087433 cites W2165186407 @default.
- W2137087433 cites W2168025729 @default.
- W2137087433 cites W2169152986 @default.
- W2137087433 cites W2319723556 @default.
- W2137087433 cites W4294550630 @default.
- W2137087433 doi "https://doi.org/10.1039/c1nr11029b" @default.
- W2137087433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21952557" @default.
- W2137087433 hasPublicationYear "2011" @default.
- W2137087433 type Work @default.
- W2137087433 sameAs 2137087433 @default.
- W2137087433 citedByCount "25" @default.
- W2137087433 countsByYear W21370874332012 @default.
- W2137087433 countsByYear W21370874332013 @default.
- W2137087433 countsByYear W21370874332014 @default.
- W2137087433 countsByYear W21370874332015 @default.
- W2137087433 countsByYear W21370874332016 @default.
- W2137087433 countsByYear W21370874332017 @default.
- W2137087433 countsByYear W21370874332019 @default.
- W2137087433 countsByYear W21370874332020 @default.
- W2137087433 countsByYear W21370874332022 @default.
- W2137087433 countsByYear W21370874332023 @default.
- W2137087433 crossrefType "journal-article" @default.
- W2137087433 hasAuthorship W2137087433A5021449466 @default.
- W2137087433 hasAuthorship W2137087433A5027066046 @default.
- W2137087433 hasAuthorship W2137087433A5031398448 @default.
- W2137087433 hasAuthorship W2137087433A5040817099 @default.
- W2137087433 hasAuthorship W2137087433A5085898674 @default.
- W2137087433 hasConcept C109316439 @default.
- W2137087433 hasConcept C12554922 @default.
- W2137087433 hasConcept C171250308 @default.
- W2137087433 hasConcept C178790620 @default.
- W2137087433 hasConcept C185592680 @default.
- W2137087433 hasConcept C192562407 @default.
- W2137087433 hasConcept C202751555 @default.
- W2137087433 hasConcept C2779281246 @default.
- W2137087433 hasConcept C2779491297 @default.
- W2137087433 hasConcept C2780642029 @default.
- W2137087433 hasConcept C29730261 @default.
- W2137087433 hasConcept C45206210 @default.
- W2137087433 hasConcept C48349386 @default.
- W2137087433 hasConcept C544778455 @default.
- W2137087433 hasConcept C55493867 @default.
- W2137087433 hasConcept C86803240 @default.
- W2137087433 hasConceptScore W2137087433C109316439 @default.
- W2137087433 hasConceptScore W2137087433C12554922 @default.
- W2137087433 hasConceptScore W2137087433C171250308 @default.
- W2137087433 hasConceptScore W2137087433C178790620 @default.
- W2137087433 hasConceptScore W2137087433C185592680 @default.
- W2137087433 hasConceptScore W2137087433C192562407 @default.
- W2137087433 hasConceptScore W2137087433C202751555 @default.
- W2137087433 hasConceptScore W2137087433C2779281246 @default.
- W2137087433 hasConceptScore W2137087433C2779491297 @default.