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- W2137096448 endingPage "1605" @default.
- W2137096448 startingPage "1595" @default.
- W2137096448 abstract "Life-history theory and evolutionary theories of aging assume the existence of alleles with age-specific effects on fitness. While various studies have documented age-related changes in the genetic contribution to variation in fitness components, we know very little about the underlying genetic architecture of such changes. We used a set of recombinant inbred lines to map and characterize the effects of quantitative trait loci (QTL) affecting fecundity of Drosophila melanogaster females at 1 and 4 weeks of age. We identified one QTL on the second chromosome and one or two QTL affecting fecundity on the third chromosome, but these QTL affected fecundity only at 1 week of age. There was more genetic variation for fecundity at 4 weeks of age than at 1 week of age and there was no genetic correlation between early and late-age fecundity. These results suggest that different loci contribute to the variation in fecundity as the organism ages. Our data provide support for the mutation accumulation theory of aging as applied to reproductive senescence. Comparing the results from this study with our previous work on life-span QTL, we also find evidence that antagonistic pleiotropy may contribute to the genetic basis of senescence in these lines as well." @default.
- W2137096448 created "2016-06-24" @default.
- W2137096448 creator A5028037557 @default.
- W2137096448 creator A5074737428 @default.
- W2137096448 creator A5082614697 @default.
- W2137096448 date "2006-03-01" @default.
- W2137096448 modified "2023-10-16" @default.
- W2137096448 title "Quantitative Trait Loci With Age-Specific Effects on Fecundity in <i>Drosophila melanogaster</i>" @default.
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