FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137106310> ?p ?o ?g. }

• W2137106310 endingPage "1653" @default.
• W2137106310 startingPage "1641" @default.
• W2137106310 abstract "The E2F1 transcription factor, which was originally identified as a cell-cycle initiator, mediates apoptosis in response to DNA damage. As E2F1-induced apoptosis is an attractive mechanism for cancer therapy, it is critical to fully elucidate its effector pathways. Here, we show that the c-MYC-interacting proapoptotic tumor suppressor, BIN1, is transcriptionally activated by E2F1 and mediates E2F1-induced apoptosis in response to DNA damage. Acting through the DNA-binding and transactivation domains, ectopically expressed E2F1 activated the human BIN1 promoter, which contains canonical E2F-recognition sites. Conversely, depletion of E2F1 by small interfering RNA or germline deletion led to BIN1 deficiency. DNA-damaging agents (which included etoposide) increased BIN1 levels, unless E2F1 was deficient. Moreover, endogenous E2F1 protein interacted directly with the BIN1 gene promoter in chromatin, particularly after etoposide treatment. Notably, suppression of BIN1 expression using an antisense (AS) technique attenuated the cell death mediated by E2F1 and etoposide. Although the p53 tumor suppressor, its sibling protein p73, and caspases are well-known E2F1 effectors for DNA damage-induced apoptosis, AS-BIN1 did not compromise their apoptotic functions. Our results collectively suggest that BIN1 is a novel transcriptional target of E2F1 that triggers a unique mode of cell death in response to DNA damage." @default.
• W2137106310 created "2016-06-24" @default.
• W2137106310 creator A5019445232 @default.
• W2137106310 creator A5023214532 @default.
• W2137106310 creator A5072738885 @default.
• W2137106310 date "2009-07-24" @default.
• W2137106310 modified "2023-10-16" @default.
• W2137106310 title "The c-MYC-interacting proapoptotic tumor suppressor BIN1 is a transcriptional target for E2F1 in response to DNA damage" @default.
• W2137106310 cites W1507706498 @default.
• W2137106310 cites W1905622470 @default.
• W2137106310 cites W1905653829 @default.
• W2137106310 cites W1966419893 @default.
• W2137106310 cites W1970841420 @default.
• W2137106310 cites W1972402664 @default.
• W2137106310 cites W1976180248 @default.
• W2137106310 cites W1980759602 @default.
• W2137106310 cites W1982989725 @default.
• W2137106310 cites W1989147967 @default.
• W2137106310 cites W1990280364 @default.
• W2137106310 cites W2029383449 @default.
• W2137106310 cites W2030844021 @default.
• W2137106310 cites W2040588918 @default.
• W2137106310 cites W2054034728 @default.
• W2137106310 cites W2070422421 @default.
• W2137106310 cites W2083629160 @default.
• W2137106310 cites W2089040920 @default.
• W2137106310 cites W2092124718 @default.
• W2137106310 cites W2098470595 @default.
• W2137106310 cites W2098716855 @default.
• W2137106310 cites W2100646314 @default.
• W2137106310 cites W2104519300 @default.
• W2137106310 cites W2105902888 @default.
• W2137106310 cites W2108796882 @default.
• W2137106310 cites W2110744505 @default.
• W2137106310 cites W2137022580 @default.
• W2137106310 cites W2137530154 @default.
• W2137106310 cites W2147853500 @default.
• W2137106310 cites W2156016682 @default.
• W2137106310 cites W2159235132 @default.
• W2137106310 cites W2160042914 @default.
• W2137106310 cites W2161080185 @default.
• W2137106310 cites W2169484696 @default.
• W2137106310 cites W2313167421 @default.
• W2137106310 cites W2318845086 @default.
• W2137106310 cites W2326889571 @default.
• W2137106310 doi "https://doi.org/10.1038/cdd.2009.98" @default.
• W2137106310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19629135" @default.
• W2137106310 hasPublicationYear "2009" @default.
• W2137106310 type Work @default.
• W2137106310 sameAs 2137106310 @default.
• W2137106310 citedByCount "31" @default.
• W2137106310 countsByYear W21371063102012 @default.
• W2137106310 countsByYear W21371063102013 @default.
• W2137106310 countsByYear W21371063102014 @default.
• W2137106310 countsByYear W21371063102015 @default.
• W2137106310 countsByYear W21371063102017 @default.
• W2137106310 countsByYear W21371063102018 @default.
• W2137106310 countsByYear W21371063102019 @default.
• W2137106310 countsByYear W21371063102020 @default.
• W2137106310 countsByYear W21371063102021 @default.
• W2137106310 countsByYear W21371063102022 @default.
• W2137106310 countsByYear W21371063102023 @default.
• W2137106310 crossrefType "journal-article" @default.
• W2137106310 hasAuthorship W2137106310A5019445232 @default.
• W2137106310 hasAuthorship W2137106310A5023214532 @default.
• W2137106310 hasAuthorship W2137106310A5072738885 @default.
• W2137106310 hasBestOaLocation W21371063101 @default.
• W2137106310 hasConcept C104317684 @default.
• W2137106310 hasConcept C1292079 @default.
• W2137106310 hasConcept C143425029 @default.
• W2137106310 hasConcept C153911025 @default.
• W2137106310 hasConcept C183022183 @default.
• W2137106310 hasConcept C190283241 @default.
• W2137106310 hasConcept C29537977 @default.
• W2137106310 hasConcept C502942594 @default.
• W2137106310 hasConcept C51785407 @default.
• W2137106310 hasConcept C54355233 @default.
• W2137106310 hasConcept C552990157 @default.
• W2137106310 hasConcept C83258922 @default.
• W2137106310 hasConcept C86339819 @default.
• W2137106310 hasConcept C86803240 @default.
• W2137106310 hasConcept C95444343 @default.
• W2137106310 hasConceptScore W2137106310C104317684 @default.
• W2137106310 hasConceptScore W2137106310C1292079 @default.
• W2137106310 hasConceptScore W2137106310C143425029 @default.
• W2137106310 hasConceptScore W2137106310C153911025 @default.
• W2137106310 hasConceptScore W2137106310C183022183 @default.
• W2137106310 hasConceptScore W2137106310C190283241 @default.
• W2137106310 hasConceptScore W2137106310C29537977 @default.
• W2137106310 hasConceptScore W2137106310C502942594 @default.
• W2137106310 hasConceptScore W2137106310C51785407 @default.
• W2137106310 hasConceptScore W2137106310C54355233 @default.
• W2137106310 hasConceptScore W2137106310C552990157 @default.
• W2137106310 hasConceptScore W2137106310C83258922 @default.
• W2137106310 hasConceptScore W2137106310C86339819 @default.
• W2137106310 hasConceptScore W2137106310C86803240 @default.
• W2137106310 hasConceptScore W2137106310C95444343 @default.
• W2137106310 hasIssue "12" @default.

• next