FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137107266> ?p ?o ?g. }

• W2137107266 endingPage "98" @default.
• W2137107266 startingPage "93" @default.
• W2137107266 abstract "Induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs) are two types of pluripotent stem cells that hold great promise for biomedical research and medical applications. iPSCs were initially favorably compared to ESCs. This view was first based on ethical arguments (the generation of iPSCs does not require the destruction of an embryo) and on immunological reasons (it is easier to derive patient HLA-matched iPSCs than ESCs). However, several reports suggest that iPSCs might be characterized by higher occurrence of epigenetic and genetic aberrations than ESCs as a consequence of the reprogramming process. We focus here on the DNA integrity of pluripotent stem cells and examine the three main sources of genomic abnormalities in iPSCs: (1) genomic variety of the parental cells, (2) cell reprogramming, and (3) in vitro cell culture. Recent reports claim that it is possible to generate mouse or human iPSC lines with a mutation level similar to that of the parental cells, suggesting that “genome-friendly” reprogramming techniques can be developed. The issue of iPSC DNA integrity clearly highlights the crucial need of guidelines to define the acceptable level of genomic integrity of pluripotent stem cells for biomedical applications. We discuss here the main issues that such guidelines should address. Keywords: Induced pluripotent stem cells, cell reprogramming, genetic abnormalities, pluripotency, DNA damage, genome integrity" @default.
• W2137107266 created "2016-06-24" @default.
• W2137107266 creator A5012337436 @default.
• W2137107266 creator A5018942492 @default.
• W2137107266 creator A5030135901 @default.
• W2137107266 creator A5051212502 @default.
• W2137107266 creator A5085684624 @default.
• W2137107266 date "2013-03-01" @default.
• W2137107266 modified "2023-10-16" @default.
• W2137107266 title "Embryonic Stem Cells or Induced Pluripotent Stem Cells? A DNA Integrity Perspective" @default.
• W2137107266 cites W1877320158 @default.
• W2137107266 cites W1964294710 @default.
• W2137107266 cites W1967025085 @default.
• W2137107266 cites W1967467247 @default.
• W2137107266 cites W1969892080 @default.
• W2137107266 cites W1971531553 @default.
• W2137107266 cites W1984197757 @default.
• W2137107266 cites W1986371962 @default.
• W2137107266 cites W1986832923 @default.
• W2137107266 cites W1987523847 @default.
• W2137107266 cites W1989773675 @default.
• W2137107266 cites W1991037959 @default.
• W2137107266 cites W1999038855 @default.
• W2137107266 cites W1999389272 @default.
• W2137107266 cites W2025251914 @default.
• W2137107266 cites W2028835848 @default.
• W2137107266 cites W2029404434 @default.
• W2137107266 cites W2032570745 @default.
• W2137107266 cites W2037338370 @default.
• W2137107266 cites W2041418779 @default.
• W2137107266 cites W2044877927 @default.
• W2137107266 cites W2045048112 @default.
• W2137107266 cites W2045899482 @default.
• W2137107266 cites W2048263005 @default.
• W2137107266 cites W2049358079 @default.
• W2137107266 cites W2050160133 @default.
• W2137107266 cites W2050689355 @default.
• W2137107266 cites W2051893135 @default.
• W2137107266 cites W2052159842 @default.
• W2137107266 cites W2053911973 @default.
• W2137107266 cites W2054059225 @default.
• W2137107266 cites W2058981318 @default.
• W2137107266 cites W2059378220 @default.
• W2137107266 cites W2061824613 @default.
• W2137107266 cites W2062942287 @default.
• W2137107266 cites W2065796189 @default.
• W2137107266 cites W2066413879 @default.
• W2137107266 cites W2072239613 @default.
• W2137107266 cites W2074563708 @default.
• W2137107266 cites W2076047032 @default.
• W2137107266 cites W2078858529 @default.
• W2137107266 cites W2081620485 @default.
• W2137107266 cites W2086663462 @default.
• W2137107266 cites W2086943348 @default.
• W2137107266 cites W2088510748 @default.
• W2137107266 cites W2089486322 @default.
• W2137107266 cites W2092780119 @default.
• W2137107266 cites W2096910509 @default.
• W2137107266 cites W2098597036 @default.
• W2137107266 cites W2103540918 @default.
• W2137107266 cites W2108732901 @default.
• W2137107266 cites W2111920812 @default.
• W2137107266 cites W2114840727 @default.
• W2137107266 cites W2117460005 @default.
• W2137107266 cites W2119656037 @default.
• W2137107266 cites W2125987139 @default.
• W2137107266 cites W2137440275 @default.
• W2137107266 cites W2138088258 @default.
• W2137107266 cites W2138977668 @default.
• W2137107266 cites W2151510743 @default.
• W2137107266 cites W2158979552 @default.
• W2137107266 cites W2163404991 @default.
• W2137107266 cites W2268150225 @default.
• W2137107266 doi "https://doi.org/10.2174/1566523211313020003" @default.
• W2137107266 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3947934" @default.
• W2137107266 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23317057" @default.
• W2137107266 hasPublicationYear "2013" @default.
• W2137107266 type Work @default.
• W2137107266 sameAs 2137107266 @default.
• W2137107266 citedByCount "45" @default.
• W2137107266 countsByYear W21371072662013 @default.
• W2137107266 countsByYear W21371072662014 @default.
• W2137107266 countsByYear W21371072662015 @default.
• W2137107266 countsByYear W21371072662016 @default.
• W2137107266 countsByYear W21371072662017 @default.
• W2137107266 countsByYear W21371072662018 @default.
• W2137107266 countsByYear W21371072662019 @default.
• W2137107266 countsByYear W21371072662020 @default.
• W2137107266 countsByYear W21371072662021 @default.
• W2137107266 countsByYear W21371072662022 @default.
• W2137107266 countsByYear W21371072662023 @default.
• W2137107266 crossrefType "journal-article" @default.
• W2137107266 hasAuthorship W2137107266A5012337436 @default.
• W2137107266 hasAuthorship W2137107266A5018942492 @default.
• W2137107266 hasAuthorship W2137107266A5030135901 @default.
• W2137107266 hasAuthorship W2137107266A5051212502 @default.
• W2137107266 hasAuthorship W2137107266A5085684624 @default.
• W2137107266 hasBestOaLocation W21371072662 @default.

• next