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• W2137118919 abstract "In reaction to the marketing suspension recommended by the European Medicines Agency, Genentech announced the voluntary withdrawal of efalizumab. Since June 8, 2009, efalizumab has been unavailable. Despite the fact that the use of efalizumab is now ceased, results of studies with efalizumab will remain relevant, especially about its use in an off-label setting for indications other then chronic plaque psoriasis. New biologics as well as chemicals are being developed targeting similar T-cell-mediated pathways. Indications for these new compounds other than chronic plaque psoriasis could be selected based on this systematic review. With this article we aimed to summarize the evidence of effectiveness and/or the efficacy and safety of efalizumab in off-label dermatological use, and to illustrate the time scale in which dermatological medicines are offered off-label to dermatological patients. We found some evidence supporting the effectiveness of efalizumab in palmoplantar pustulosis, atopic dermatitis, lichen planus and cutaneous lupus erythematosus. In total, 12 serious adverse events occurred, one due to an infection. Efalizumab was given off-label within half a year after registration of the drug for plaque psoriasis." @default.
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• W2137118919 date "2010-10-01" @default.
• W2137118919 modified "2023-09-23" @default.
• W2137118919 title "Off-label use of efalizumab in dermatology" @default.
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• W2137118919 doi "https://doi.org/10.1586/edm.10.44" @default.
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