FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137121443> ?p ?o ?g. }

• W2137121443 endingPage "587" @default.
• W2137121443 startingPage "579" @default.
• W2137121443 abstract "Increased levels of several pro-inflammatory cytokines including interleukin-1β (IL-1β) and tumour necrosis factor-α (TNFα) have been found in bronchoalveolar lavage fluid from symptomatic asthmatic patients. IL-1β, TNFα and interferon-γ (IFNγ) are known to stimulate a number of cells to produce inflammatory mediators such as prostaglandins. Although airway smooth muscle (ASM) is known to be a rich source of prostaglandins, the regulation of cyclo-oxygenase (COX) isoforms and prostanoid production by proinflammatory cytokines have not been studied in human airway smooth muscle. We studied the effects of IL-1β, TNFα and IFNγ on the induction of two isoforms of cyclo-oxygenase and its relation to prostaglandin E2 (PGE2) release and COX activity (reflected by PGE2 synthesis from exogenous arachidonic acid) in human cultured airway smooth muscle cells. IL-1β, but not TNFα or IFNγ, caused a time- and concentration-dependent enhancement in PGE2 and other prostanoid (6-keto-PGF1α, PGF2α, thromboxane B2 (TXB2) and PGD2) production, with PGE2 and 6-keto-PGF1α as the principal products. This stimulation was accompanied by a corresponding increase in COX activity. COX-2 protein measured by Western blot analysis was not detectable in untreated cells, but was increased in a time- and concentration-dependent manner by IL-1β, but not TNFα or IFNγ. In contrast, no variation in the expression of COX-1 protein was observed. Pretreatment with the conventional non-steroidal anti-inflammatory drugs (NSAIDs), indomethacin and ibuprofen, and the selective COX-2 inhibitors, NS-398 and nimesulide, completely blocked IL-1β-induced PGE2 release and COX activity. The glucocorticosteroid dexamethasone and protein synthesis inhibitors, cycloheximide and actinomycin D, not only markedly inhibited IL-1β-stimulated PGE2 release and COX activity but also suppressed IL-1β-induced COX-2 induction. This study demonstrates that human cultured ASM cells release prostanoids in response to IL-1β stimulation and that the response is mostly mediated by the induction of COX-2 rather than COX-1 isoenzyme, implying that airway smooth muscle may be an important source of prostaglandins in human airways and that COX-2 may play an important role in the regulation of the inflammatory process in asthma." @default.
• W2137121443 created "2016-06-24" @default.
• W2137121443 creator A5071572427 @default.
• W2137121443 creator A5079846677 @default.
• W2137121443 date "1997-05-01" @default.
• W2137121443 modified "2023-09-29" @default.
• W2137121443 title "Effect of interleukin-1<i>β</i> , tumour necrosis factor-<i>α</i> and interferon-γ on the induction of cyclo-oxygenase-2 in cultured human airway smooth muscle cells" @default.
• W2137121443 cites W1494920110 @default.
• W2137121443 cites W164399760 @default.
• W2137121443 cites W1657740120 @default.
• W2137121443 cites W1968128488 @default.
• W2137121443 cites W1978219061 @default.
• W2137121443 cites W1983865870 @default.
• W2137121443 cites W1990174772 @default.
• W2137121443 cites W1997214991 @default.
• W2137121443 cites W1997814407 @default.
• W2137121443 cites W2002562116 @default.
• W2137121443 cites W2002947342 @default.
• W2137121443 cites W2013701105 @default.
• W2137121443 cites W2016253529 @default.
• W2137121443 cites W2019632917 @default.
• W2137121443 cites W2041102059 @default.
• W2137121443 cites W2048152958 @default.
• W2137121443 cites W2051086902 @default.
• W2137121443 cites W2054206927 @default.
• W2137121443 cites W2057068263 @default.
• W2137121443 cites W2063656508 @default.
• W2137121443 cites W2064871821 @default.
• W2137121443 cites W2071654344 @default.
• W2137121443 cites W2072571448 @default.
• W2137121443 cites W2080375787 @default.
• W2137121443 cites W2085868451 @default.
• W2137121443 cites W2092304550 @default.
• W2137121443 cites W2111144017 @default.
• W2137121443 cites W2113745276 @default.
• W2137121443 cites W2126672298 @default.
• W2137121443 cites W2158686638 @default.
• W2137121443 cites W2159108574 @default.
• W2137121443 cites W2160363614 @default.
• W2137121443 cites W2413862754 @default.
• W2137121443 cites W85029217 @default.
• W2137121443 doi "https://doi.org/10.1038/sj.bjp.0701152" @default.
• W2137121443 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1564708" @default.
• W2137121443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9179403" @default.
• W2137121443 hasPublicationYear "1997" @default.
• W2137121443 type Work @default.
• W2137121443 sameAs 2137121443 @default.
• W2137121443 citedByCount "167" @default.
• W2137121443 countsByYear W21371214432012 @default.
• W2137121443 countsByYear W21371214432014 @default.
• W2137121443 countsByYear W21371214432015 @default.
• W2137121443 countsByYear W21371214432016 @default.
• W2137121443 countsByYear W21371214432017 @default.
• W2137121443 countsByYear W21371214432018 @default.
• W2137121443 countsByYear W21371214432019 @default.
• W2137121443 countsByYear W21371214432020 @default.
• W2137121443 countsByYear W21371214432021 @default.
• W2137121443 countsByYear W21371214432022 @default.
• W2137121443 crossrefType "journal-article" @default.
• W2137121443 hasAuthorship W2137121443A5071572427 @default.
• W2137121443 hasAuthorship W2137121443A5079846677 @default.
• W2137121443 hasBestOaLocation W21371214432 @default.
• W2137121443 hasConcept C126322002 @default.
• W2137121443 hasConcept C134018914 @default.
• W2137121443 hasConcept C164027704 @default.
• W2137121443 hasConcept C17991360 @default.
• W2137121443 hasConcept C181199279 @default.
• W2137121443 hasConcept C185592680 @default.
• W2137121443 hasConcept C2776352991 @default.
• W2137121443 hasConcept C2776914184 @default.
• W2137121443 hasConcept C2777361909 @default.
• W2137121443 hasConcept C2777956040 @default.
• W2137121443 hasConcept C2778078955 @default.
• W2137121443 hasConcept C2778266237 @default.
• W2137121443 hasConcept C2778690821 @default.
• W2137121443 hasConcept C2779689624 @default.
• W2137121443 hasConcept C2780664492 @default.
• W2137121443 hasConcept C55493867 @default.
• W2137121443 hasConcept C71924100 @default.
• W2137121443 hasConcept C74172505 @default.
• W2137121443 hasConcept C86803240 @default.
• W2137121443 hasConceptScore W2137121443C126322002 @default.
• W2137121443 hasConceptScore W2137121443C134018914 @default.
• W2137121443 hasConceptScore W2137121443C164027704 @default.
• W2137121443 hasConceptScore W2137121443C17991360 @default.
• W2137121443 hasConceptScore W2137121443C181199279 @default.
• W2137121443 hasConceptScore W2137121443C185592680 @default.
• W2137121443 hasConceptScore W2137121443C2776352991 @default.
• W2137121443 hasConceptScore W2137121443C2776914184 @default.
• W2137121443 hasConceptScore W2137121443C2777361909 @default.
• W2137121443 hasConceptScore W2137121443C2777956040 @default.
• W2137121443 hasConceptScore W2137121443C2778078955 @default.
• W2137121443 hasConceptScore W2137121443C2778266237 @default.
• W2137121443 hasConceptScore W2137121443C2778690821 @default.
• W2137121443 hasConceptScore W2137121443C2779689624 @default.
• W2137121443 hasConceptScore W2137121443C2780664492 @default.
• W2137121443 hasConceptScore W2137121443C55493867 @default.
• W2137121443 hasConceptScore W2137121443C71924100 @default.

• next