FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137126095> ?p ?o ?g. }

• W2137126095 abstract "Cyclooxygenase-2 (COX-2) enzyme over expression is reported in many human HCC cell line studies and is linked to tumor cell resistance to chemotherapy-induced apoptosis. We hypothesized that adding a COX-2 inhibitor would improve the therapeutic benefits in patients with HCC. COX-2 is often increased and involved in drug resistance and poor prognosis.Between January 2001 and December 2007, 15 patients with MDR-positive-HCC from 34 HCC patients based on tissue and serum liver of glypican-3 and fitting the preset eligibility criteria, were treated with a combination regimen with intravenous infusion of (5-FU) 750 mg once per week, 100mg/day cyclophosphamide (Endoxan) and 400 mg/day celecoxib taken orally in divided doses, while the rest of the patients received only 5-FU and Endoxan. Twenty-one patients (62%) had liver disease associated with hepatitis C virus (HCV) and 5 patients with hepatitis B virus (62%).We found that celecoxib reduced P-glycoprotein with activation of caspase-3 and marked regression of tumor sizes. Sera angiogenic factors (VEGF & bFGF) levels measurement in HCC patients indicated that, the sera levels of both angiogenic factors were reduced significantly (p < 0.05) after treatment. Based on the tumor markers AFP & Glypican-3, 11 of the patients had a PR (11/15), including 3 patients who had normalization of AFP, and four patients had CR (4/15).These data suggest that the combination of 5-FU, Endoxan and Celecoxib is highly effective palliative regimen for patients with HCC with good performance status (score ≤ 3). The study suggests a framework for Celecoxib-based combination treatment of HCC." @default.
• W2137126095 created "2016-06-24" @default.
• W2137126095 creator A5050862995 @default.
• W2137126095 creator A5064310163 @default.
• W2137126095 creator A5064998040 @default.
• W2137126095 date "2010-10-01" @default.
• W2137126095 modified "2023-09-26" @default.
• W2137126095 title "Synergistic Effect of Celecoxib on 5-fluorouracil-induced Apoptosis in Hepatocellular Carcinoma Patients" @default.
• W2137126095 cites W1482578950 @default.
• W2137126095 cites W1561881745 @default.
• W2137126095 cites W1965891737 @default.
• W2137126095 cites W1965976308 @default.
• W2137126095 cites W1983109993 @default.
• W2137126095 cites W1986702838 @default.
• W2137126095 cites W2009974292 @default.
• W2137126095 cites W2014308148 @default.
• W2137126095 cites W2017505256 @default.
• W2137126095 cites W2033791403 @default.
• W2137126095 cites W2047141741 @default.
• W2137126095 cites W2049388096 @default.
• W2137126095 cites W2053643795 @default.
• W2137126095 cites W2055027970 @default.
• W2137126095 cites W2076668534 @default.
• W2137126095 cites W2080587798 @default.
• W2137126095 cites W2080992186 @default.
• W2137126095 cites W2085301972 @default.
• W2137126095 cites W2087711359 @default.
• W2137126095 cites W2095839230 @default.
• W2137126095 cites W2097295926 @default.
• W2137126095 cites W2104475833 @default.
• W2137126095 cites W2104819002 @default.
• W2137126095 cites W2114939751 @default.
• W2137126095 cites W2126330431 @default.
• W2137126095 cites W2127558096 @default.
• W2137126095 cites W2139248078 @default.
• W2137126095 cites W2165663767 @default.
• W2137126095 cites W2166030420 @default.
• W2137126095 cites W2411580384 @default.
• W2137126095 cites W336701656 @default.
• W2137126095 doi "https://doi.org/10.1016/s1665-2681(19)31617-5" @default.
• W2137126095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21057160" @default.
• W2137126095 hasPublicationYear "2010" @default.
• W2137126095 type Work @default.
• W2137126095 sameAs 2137126095 @default.
• W2137126095 citedByCount "22" @default.
• W2137126095 countsByYear W21371260952012 @default.
• W2137126095 countsByYear W21371260952013 @default.
• W2137126095 countsByYear W21371260952014 @default.
• W2137126095 countsByYear W21371260952015 @default.
• W2137126095 countsByYear W21371260952017 @default.
• W2137126095 countsByYear W21371260952018 @default.
• W2137126095 countsByYear W21371260952019 @default.
• W2137126095 countsByYear W21371260952020 @default.
• W2137126095 countsByYear W21371260952021 @default.
• W2137126095 crossrefType "journal-article" @default.
• W2137126095 hasAuthorship W2137126095A5050862995 @default.
• W2137126095 hasAuthorship W2137126095A5064310163 @default.
• W2137126095 hasAuthorship W2137126095A5064998040 @default.
• W2137126095 hasBestOaLocation W21371260951 @default.
• W2137126095 hasConcept C126322002 @default.
• W2137126095 hasConcept C143998085 @default.
• W2137126095 hasConcept C185592680 @default.
• W2137126095 hasConcept C190283241 @default.
• W2137126095 hasConcept C2776467144 @default.
• W2137126095 hasConcept C2776694085 @default.
• W2137126095 hasConcept C2776755627 @default.
• W2137126095 hasConcept C2778019345 @default.
• W2137126095 hasConcept C2781413609 @default.
• W2137126095 hasConcept C55493867 @default.
• W2137126095 hasConcept C71924100 @default.
• W2137126095 hasConcept C90924648 @default.
• W2137126095 hasConceptScore W2137126095C126322002 @default.
• W2137126095 hasConceptScore W2137126095C143998085 @default.
• W2137126095 hasConceptScore W2137126095C185592680 @default.
• W2137126095 hasConceptScore W2137126095C190283241 @default.
• W2137126095 hasConceptScore W2137126095C2776467144 @default.
• W2137126095 hasConceptScore W2137126095C2776694085 @default.
• W2137126095 hasConceptScore W2137126095C2776755627 @default.
• W2137126095 hasConceptScore W2137126095C2778019345 @default.
• W2137126095 hasConceptScore W2137126095C2781413609 @default.
• W2137126095 hasConceptScore W2137126095C55493867 @default.
• W2137126095 hasConceptScore W2137126095C71924100 @default.
• W2137126095 hasConceptScore W2137126095C90924648 @default.
• W2137126095 hasLocation W21371260951 @default.
• W2137126095 hasLocation W21371260952 @default.
• W2137126095 hasOpenAccess W2137126095 @default.
• W2137126095 hasPrimaryLocation W21371260951 @default.
• W2137126095 hasRelatedWork W1507502327 @default.
• W2137126095 hasRelatedWork W164410617 @default.
• W2137126095 hasRelatedWork W1963761658 @default.
• W2137126095 hasRelatedWork W1994193851 @default.
• W2137126095 hasRelatedWork W2019204239 @default.
• W2137126095 hasRelatedWork W2032537873 @default.
• W2137126095 hasRelatedWork W2040272299 @default.
• W2137126095 hasRelatedWork W2090735366 @default.
• W2137126095 hasRelatedWork W2092313930 @default.
• W2137126095 hasRelatedWork W2099413737 @default.
• W2137126095 hasRelatedWork W2109479504 @default.
• W2137126095 hasRelatedWork W2148499942 @default.
• W2137126095 hasRelatedWork W2197145779 @default.

• next