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- W2137129218 abstract "<h3>Hypothesis</h3> Cyclooxygenase 2 (COX-2), vascular endothelial growth factor (VEGF), and epidermal growth factor receptor (EGFR) are useful biological determinants in targeted therapy for esophageal adenocarcinoma. <h3>Design</h3> Prospective analysis. <h3>Setting</h3> University tertiary referral center. <h3>Patients</h3> Sixteen patients with squamous mucosa and normal results of a pH study without mucosal injury (control group), 15 with Barrett esophagus (metaplasia group), and 44 with adenocarcinoma (carcinoma group). <h3>Interventions</h3> Biopsy specimens were obtained 3 cm above the gastroesophageal junction. Dysplastic tissue was additionally isolated from 9 of the patients in the carcinoma group. After laser-capture microdissection, quantitative real-time polymerase chain reaction was used to measure gene expression across the spectrum of the metaplasia-dysplasia-carcinoma sequence. <h3>Main Outcome Measures</h3> Expression of COX-2, VEGF, and EGFR in each patient group. <h3>Results</h3> Expression of both COX-2 and VEGF was significantly up-regulated in patients with metaplasia, dysplasia, and cancer compared with controls (<i>P</i><.01). Expression levels of both were significantly higher in cancer than in the metaplasia group (<i>P</i><.05) and increased sequentially from metaplasia to dysplasia to cancer. Expression of VEGF was significantly higher in the dysplastic tissue than in nondysplastic Barrett epithelium (<i>P</i><.05). No change in expression levels of EGFR was seen in the histologic progression to esophageal adenocarcinoma. <h3>Conclusion</h3> Gene expression data suggest that pharmacologic inhibition of COX-2 and VEGF may be useful adjuncts in targeted therapy for esophageal adenocarcinoma." @default.
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- W2137129218 date "2006-05-01" @default.
- W2137129218 modified "2023-10-11" @default.
- W2137129218 title "Molecular Determinants in Targeted Therapy for Esophageal Adenocarcinoma" @default.
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- W2137129218 doi "https://doi.org/10.1001/archsurg.141.5.476" @default.
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