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• W2137130997 abstract "BACKGROUND: Infertile women positive for thyroid antibodies suffer from a poor pregnancy/delivery outcome, although conflicting data have been published. Our objective was to investigate if levothyroxine (LT4) exerts any effect on pregnancy and/or delivery rates in thyroid peroxidase antibody (TPOAb)-positive (+) women undergoing assisted reproductive technologies. METHODS: Patients undergoing treatment were screened for TPOAb, thyroid-stimulating hormone (TSH) and free thyroxine (FT4). A total of 72 (15%) out of the 484 euthyroid women selected were TPOAb (+). These 72 patients were randomly divided into two groups: group A (n=36) underwent LT4 treatment, group B (n=36) placebo. Group C consisted of 412 women (85%) who were TPOAb negative (−). All patients received controlled ovarian stimulation. The endpoints of treatment were pregnancy rate, miscarriage rate and delivery rate. RESULTS: No differences in pregnancy rate were observed between the three groups. Miscarriage rate was higher in TPOAb (+) in comparison to TPOAb (−) [relative risk: 2.01 (95% CI = 1.13–3.56), P=0.028]. CONCLUSIONS: The pregnancy rate is not affected either by presence of TPOAb or treatment with LT4. However, TPOAb (+) women show a poorer delivery rate compared to TPOAb (−). LT4 treatment in TPOAb (+) does not affect the delivery rate." @default.
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• W2137130997 date "2005-06-01" @default.
• W2137130997 modified "2023-10-12" @default.
• W2137130997 title "Levothyroxine treatment in thyroid peroxidase antibody-positive women undergoing assisted reproduction technologies: a prospective study" @default.
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• W2137130997 doi "https://doi.org/10.1093/humrep/deh843" @default.
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