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• W2137132053 endingPage "917" @default.
• W2137132053 startingPage "895" @default.
• W2137132053 abstract "Importance of the filed: According to a 2006 survey report of pharmaceutical companies, hepatotoxicity was ranked first in terms of adverse events and it remains the most common reason for restriction or withdrawal of a drug from the market by the FDA. Although there are many reasons underlying drug-induced hepatotoxicity, one of the most important is hepatotoxicity induced by drug metabolites.Areas covered in this review: This review highlights the unexpected evidence showing that > 64 allopathic drugs out of 900 can induce potentially life-threatening hepatotoxicity with diverse clinical features. In parallel, we demonstrate the use of a two-compartment organotypical model for monitoring drug biotransformation and the status of parent drugs or drug metabolites (reactive or stable metabolites).What the reader will gain: The reader will gain knowledge of the importance of the two-compartment model with special reference to drug metabolites and become aware of the hepatotoxicity of a list of allopathic drugs, many of which are presently used without prescription.Take home message: A central challenge regarding drug-induced hepatotoxicity is to understand drug metabolite formation because, although many parent drugs are not toxic, their metabolites can be toxic to liver cells following biotransformation." @default.
• W2137132053 created "2016-06-24" @default.
• W2137132053 creator A5015724313 @default.
• W2137132053 creator A5049426698 @default.
• W2137132053 creator A5061136882 @default.
• W2137132053 date "2010-04-02" @default.
• W2137132053 modified "2023-10-10" @default.
• W2137132053 title "Hepatotoxicity and hepatic metabolism of available drugs: current problems and possible solutions in preclinical stages" @default.
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