Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137132326> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2137132326 endingPage "H1177" @default.
- W2137132326 startingPage "H1172" @default.
- W2137132326 abstract "Deficiency of phospholamban (PLB) results in enhancement of basal murine cardiac function and an attenuated response to β-adrenergic stimulation. To determine whether the absence of PLB also reduces the reserve capacity of the murine cardiovascular system to respond to stress, we evaluated the heart rate (HR), blood pressure, and metabolic responses of PLB-deficient (PLB−/−) mice to graded treadmill exercise (GTE). PLB−/− mice were hypertensive at rest (125 ± 19 vs. 109 ± 16 mmHg, P < 0.05) but had normal tachycardic and hypotensive responses to isoproterenol. The HR response to GTE was normal; however, the hypertension in PLB−/− mice normalized at peak exercise. Their exercise capacities, as measured by duration of exercise and peak oxygen consumption (V˙o 2 ), were normal. The oxygen pulse (V˙o 2 /HR) curve was also normal in PLB−/− mice, suggesting an ability to appropriately increase stroke volume and oxygen extraction during GTE, despite an inability to increase β-adrenergically stimulated cardiac contractility. Thus deficiency of PLB, although resulting in diminished β-adrenergic inotropic reserve, does not compromise cardiac performance during exercise." @default.
- W2137132326 created "2016-06-24" @default.
- W2137132326 creator A5020415724 @default.
- W2137132326 creator A5057606234 @default.
- W2137132326 creator A5057873193 @default.
- W2137132326 creator A5078058630 @default.
- W2137132326 creator A5080329479 @default.
- W2137132326 date "1999-04-01" @default.
- W2137132326 modified "2023-09-25" @default.
- W2137132326 title "Phospholamban deficiency does not compromise exercise capacity" @default.
- W2137132326 cites W1859822101 @default.
- W2137132326 cites W2000486376 @default.
- W2137132326 cites W2001954861 @default.
- W2137132326 cites W2004201135 @default.
- W2137132326 cites W2005530508 @default.
- W2137132326 cites W2040215337 @default.
- W2137132326 cites W2061245367 @default.
- W2137132326 cites W2069975176 @default.
- W2137132326 cites W2114851684 @default.
- W2137132326 cites W2128916765 @default.
- W2137132326 cites W2142754357 @default.
- W2137132326 cites W2151772819 @default.
- W2137132326 cites W2168903993 @default.
- W2137132326 cites W2409671328 @default.
- W2137132326 cites W2428721686 @default.
- W2137132326 doi "https://doi.org/10.1152/ajpheart.1999.276.4.h1172" @default.
- W2137132326 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10199840" @default.
- W2137132326 hasPublicationYear "1999" @default.
- W2137132326 type Work @default.
- W2137132326 sameAs 2137132326 @default.
- W2137132326 citedByCount "28" @default.
- W2137132326 countsByYear W21371323262013 @default.
- W2137132326 countsByYear W21371323262015 @default.
- W2137132326 countsByYear W21371323262016 @default.
- W2137132326 countsByYear W21371323262018 @default.
- W2137132326 countsByYear W21371323262020 @default.
- W2137132326 crossrefType "journal-article" @default.
- W2137132326 hasAuthorship W2137132326A5020415724 @default.
- W2137132326 hasAuthorship W2137132326A5057606234 @default.
- W2137132326 hasAuthorship W2137132326A5057873193 @default.
- W2137132326 hasAuthorship W2137132326A5078058630 @default.
- W2137132326 hasAuthorship W2137132326A5080329479 @default.
- W2137132326 hasBestOaLocation W21371323262 @default.
- W2137132326 hasConcept C111566952 @default.
- W2137132326 hasConcept C126322002 @default.
- W2137132326 hasConcept C134018914 @default.
- W2137132326 hasConcept C139940330 @default.
- W2137132326 hasConcept C155710745 @default.
- W2137132326 hasConcept C164705383 @default.
- W2137132326 hasConcept C17137333 @default.
- W2137132326 hasConcept C196310339 @default.
- W2137132326 hasConcept C24998067 @default.
- W2137132326 hasConcept C2777953023 @default.
- W2137132326 hasConcept C2778198053 @default.
- W2137132326 hasConcept C39133596 @default.
- W2137132326 hasConcept C71924100 @default.
- W2137132326 hasConcept C80461066 @default.
- W2137132326 hasConcept C84393581 @default.
- W2137132326 hasConceptScore W2137132326C111566952 @default.
- W2137132326 hasConceptScore W2137132326C126322002 @default.
- W2137132326 hasConceptScore W2137132326C134018914 @default.
- W2137132326 hasConceptScore W2137132326C139940330 @default.
- W2137132326 hasConceptScore W2137132326C155710745 @default.
- W2137132326 hasConceptScore W2137132326C164705383 @default.
- W2137132326 hasConceptScore W2137132326C17137333 @default.
- W2137132326 hasConceptScore W2137132326C196310339 @default.
- W2137132326 hasConceptScore W2137132326C24998067 @default.
- W2137132326 hasConceptScore W2137132326C2777953023 @default.
- W2137132326 hasConceptScore W2137132326C2778198053 @default.
- W2137132326 hasConceptScore W2137132326C39133596 @default.
- W2137132326 hasConceptScore W2137132326C71924100 @default.
- W2137132326 hasConceptScore W2137132326C80461066 @default.
- W2137132326 hasConceptScore W2137132326C84393581 @default.
- W2137132326 hasIssue "4" @default.
- W2137132326 hasLocation W21371323261 @default.
- W2137132326 hasLocation W21371323262 @default.
- W2137132326 hasLocation W21371323263 @default.
- W2137132326 hasOpenAccess W2137132326 @default.
- W2137132326 hasPrimaryLocation W21371323261 @default.
- W2137132326 hasRelatedWork W137236334 @default.
- W2137132326 hasRelatedWork W1964263633 @default.
- W2137132326 hasRelatedWork W1982577931 @default.
- W2137132326 hasRelatedWork W2062398762 @default.
- W2137132326 hasRelatedWork W2080355098 @default.
- W2137132326 hasRelatedWork W2121467847 @default.
- W2137132326 hasRelatedWork W2136968990 @default.
- W2137132326 hasRelatedWork W2138855783 @default.
- W2137132326 hasRelatedWork W2375094068 @default.
- W2137132326 hasRelatedWork W2549257305 @default.
- W2137132326 hasVolume "276" @default.
- W2137132326 isParatext "false" @default.
- W2137132326 isRetracted "false" @default.
- W2137132326 magId "2137132326" @default.
- W2137132326 workType "article" @default.