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- W2137144164 abstract "An attempt has been made to assess Summary recent reports suggesting that Crohn's disease is transmissible. Homogenates, fresh and sterilised, of diseased and normal bowel from seven patients with Crohn's disease were inoculated into rats, guineapigs, and mice in an attempt to produce sarcoid-like granulomas at the site of inoculation. Some of the animals were immunosuppressed by juvenile thymectomy plus antilymphocyte serum, and others by cyclophosphamide. Histological examination of the site of inoculation was performed early (6-9 weeks post-inoculation), late (6-8 months after inoculation), and at post-mortem. In all, 711 sections from 295 animals were examined. No sarcoid-like granulomas were found in any specimen. These findings do not confirm the presence of a transmissible agent in Crohn's disease. It is likely that the transmissible agent previously demonstrated is not universally present in Crohn's disease." @default.
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- W2137144164 date "1973-11-01" @default.
- W2137144164 modified "2023-10-14" @default.
- W2137144164 title "NEGATIVE FINDINGS IN LABORATORY ANIMALS FOR A TRANSMISSIBLE AGENT IN CROHN'S DISEASE" @default.
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- W2137144164 doi "https://doi.org/10.1016/s0140-6736(73)90937-9" @default.
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