FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137148733> ?p ?o ?g. }

• W2137148733 endingPage "1395" @default.
• W2137148733 startingPage "1385" @default.
• W2137148733 abstract "Live attenuated nonpathogenic Mycobacterium bovis bacillus Calmette-Guérin (BCG) mediates long-lasting immune responses, has been safely administered as a tuberculosis vaccine to billions of humans, and is affordable to produce as a vaccine vector. These characteristics make it very attractive as a human immunodeficiency virus (HIV) vaccine vector candidate. Here, we assessed the immunogenicity of recombinant BCG (rBCG) constructs with different simian immunodeficiency virus (SIV)gag expression cassettes as priming agents followed by a recombinant replication-incompetent New York vaccinia virus (NYVAC) boost in rhesus macaques. Unmutated rBCG constructs were used in comparison to mutants with gene deletions identified in an in vitro screen for augmented immunogenicity. We demonstrated that BCG-SIVgag is able to elicit robust transgene-specific priming responses, resulting in strong SIV epitope-specific cellular immune responses. While enhanced immunogenicity was sustained at moderate levels for >1 year following the heterologous boost vaccination, we were unable to demonstrate a protective effect after repeated rectal mucosal challenges with pathogenic SIVmac251. Our findings highlight the potential for rBCG vaccines to stimulate effective cross-priming and enhanced major histocompatibility complex class I presentation, suggesting that combining this approach with other immunogens may contribute to the development of effective vaccine regimens against HIV." @default.
• W2137148733 created "2016-06-24" @default.
• W2137148733 creator A5007150347 @default.
• W2137148733 creator A5008989286 @default.
• W2137148733 creator A5009814810 @default.
• W2137148733 creator A5010311691 @default.
• W2137148733 creator A5012840831 @default.
• W2137148733 creator A5016158429 @default.
• W2137148733 creator A5025178490 @default.
• W2137148733 creator A5030798404 @default.
• W2137148733 creator A5034536696 @default.
• W2137148733 creator A5035889887 @default.
• W2137148733 creator A5040810749 @default.
• W2137148733 creator A5049518177 @default.
• W2137148733 creator A5051827275 @default.
• W2137148733 creator A5062495915 @default.
• W2137148733 creator A5064519786 @default.
• W2137148733 creator A5064945346 @default.
• W2137148733 creator A5070490292 @default.
• W2137148733 creator A5077334608 @default.
• W2137148733 creator A5081142838 @default.
• W2137148733 creator A5087130929 @default.
• W2137148733 creator A5091705286 @default.
• W2137148733 date "2014-10-01" @default.
• W2137148733 modified "2023-09-25" @default.
• W2137148733 title "Recombinant Mycobacterium bovis Bacillus Calmette-Guérin Vectors Prime for Strong Cellular Responses to Simian Immunodeficiency Virus Gag in Rhesus Macaques" @default.
• W2137148733 cites W1531750039 @default.
• W2137148733 cites W1587830797 @default.
• W2137148733 cites W1934542416 @default.
• W2137148733 cites W1941961496 @default.
• W2137148733 cites W1954320464 @default.
• W2137148733 cites W2003878313 @default.
• W2137148733 cites W2017269279 @default.
• W2137148733 cites W2017741849 @default.
• W2137148733 cites W2021550859 @default.
• W2137148733 cites W2023022687 @default.
• W2137148733 cites W2031206118 @default.
• W2137148733 cites W2046053895 @default.
• W2137148733 cites W2046737353 @default.
• W2137148733 cites W2054351966 @default.
• W2137148733 cites W2066973840 @default.
• W2137148733 cites W2075345074 @default.
• W2137148733 cites W2075477269 @default.
• W2137148733 cites W2078290231 @default.
• W2137148733 cites W2087337413 @default.
• W2137148733 cites W2089789348 @default.
• W2137148733 cites W2091239380 @default.
• W2137148733 cites W2093218866 @default.
• W2137148733 cites W2104823480 @default.
• W2137148733 cites W2105352387 @default.
• W2137148733 cites W2108868448 @default.
• W2137148733 cites W2114716065 @default.
• W2137148733 cites W2117556170 @default.
• W2137148733 cites W2126980226 @default.
• W2137148733 cites W2127542403 @default.
• W2137148733 cites W2128904588 @default.
• W2137148733 cites W2131674674 @default.
• W2137148733 cites W2137824026 @default.
• W2137148733 cites W2144882745 @default.
• W2137148733 cites W2151130810 @default.
• W2137148733 cites W2152048324 @default.
• W2137148733 cites W2164816719 @default.
• W2137148733 cites W2165948328 @default.
• W2137148733 cites W2168568296 @default.
• W2137148733 doi "https://doi.org/10.1128/cvi.00324-14" @default.
• W2137148733 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4266348" @default.
• W2137148733 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25080550" @default.
• W2137148733 hasPublicationYear "2014" @default.
• W2137148733 type Work @default.
• W2137148733 sameAs 2137148733 @default.
• W2137148733 citedByCount "12" @default.
• W2137148733 countsByYear W21371487332015 @default.
• W2137148733 countsByYear W21371487332017 @default.
• W2137148733 countsByYear W21371487332018 @default.
• W2137148733 countsByYear W21371487332019 @default.
• W2137148733 countsByYear W21371487332020 @default.
• W2137148733 countsByYear W21371487332021 @default.
• W2137148733 crossrefType "journal-article" @default.
• W2137148733 hasAuthorship W2137148733A5007150347 @default.
• W2137148733 hasAuthorship W2137148733A5008989286 @default.
• W2137148733 hasAuthorship W2137148733A5009814810 @default.
• W2137148733 hasAuthorship W2137148733A5010311691 @default.
• W2137148733 hasAuthorship W2137148733A5012840831 @default.
• W2137148733 hasAuthorship W2137148733A5016158429 @default.
• W2137148733 hasAuthorship W2137148733A5025178490 @default.
• W2137148733 hasAuthorship W2137148733A5030798404 @default.
• W2137148733 hasAuthorship W2137148733A5034536696 @default.
• W2137148733 hasAuthorship W2137148733A5035889887 @default.
• W2137148733 hasAuthorship W2137148733A5040810749 @default.
• W2137148733 hasAuthorship W2137148733A5049518177 @default.
• W2137148733 hasAuthorship W2137148733A5051827275 @default.
• W2137148733 hasAuthorship W2137148733A5062495915 @default.
• W2137148733 hasAuthorship W2137148733A5064519786 @default.
• W2137148733 hasAuthorship W2137148733A5064945346 @default.
• W2137148733 hasAuthorship W2137148733A5070490292 @default.
• W2137148733 hasAuthorship W2137148733A5077334608 @default.
• W2137148733 hasAuthorship W2137148733A5081142838 @default.
• W2137148733 hasAuthorship W2137148733A5087130929 @default.

• next