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- W2137152057 endingPage "80" @default.
- W2137152057 startingPage "80" @default.
- W2137152057 abstract "Interferons are proteins elaborated by infected cells that protect noninfected cells from viral infection. These proteins produce a temporary antiviral state by altering nucleotide metabolism and cytoplasmic enzyme induction. Interferons appear early after viral infection locally and systematically to limit spread of viral infection; they also affect cell differentiation, growth, surface antigen expression, morphologic findings, and immunoregulation. Several human disorders have diminished interferon production. Newborns have normal interferon alpha but deficient interferon gamma production. Infants with congenital infections may also have defects in interferon production. Immunosuppressed patients receiving transplants (marrow, heart, or kidney) have diminished interferon production, particularly immediately after transplant. Deficiencies of interferon have also been noted in Down's syndrome, cellular immunodeficiencies, uremia, malnutrition, and hematopoietic malignancy. Leukocyte interferon has been of therapeutic value in herpes zoster infections, in patients with cancer, and in patients with hepatitis B infection. Interferon has not been proved to help children with congenital cytomegalovirus or rubella. Interferon can shrink lymphoid tumors, particularly non-Hodgkin's lymphoma." @default.
- W2137152057 created "2016-06-24" @default.
- W2137152057 creator A5008280183 @default.
- W2137152057 creator A5024344697 @default.
- W2137152057 creator A5050085032 @default.
- W2137152057 creator A5054792378 @default.
- W2137152057 creator A5073866790 @default.
- W2137152057 date "1982-01-01" @default.
- W2137152057 modified "2023-10-18" @default.
- W2137152057 title "Interferon: Immunobiology and Clinical Significance" @default.
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