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- W2137153134 abstract "Objectives: Cefepime (CFPM) is being used worldwide for febrile neutropenia (FN) with three administrations per day (q8h), but because no population pharmacokinetics analysis has been performed yet, the optimal CFPM administration method remains unknown. Methods: We conducted a prospective clinical trial of CFPM among adult hematological patients with FN. CFPM was administered with a daily dose of 4 g (1 g at 10:00, 1 g at 16:00, 2 g at 22:00 hours). NONMEM software was used for the population pharmacokinetic analysis. Monte Carlo simulation was performed based on the data of minimum inhibitory concentration (MIC) frequency distribution of main bacteria strains gathered at our institute. Results: Intravenous CFPM was administered for 101 episodes of FN. A high percentage of these episodes was treated successfully (69.2%). The NONMEM program demonstrated that a 2-compartment model with CL of 4.23(L/hr), V1 of 12.0(L), Q of 3.98 (L/hr), and V2 of 3.40(L) fits the data best. Monte Carlo simulation indicated that the proportion of simulated patients with probability of attainment above target (time above MIC = 70%) was greater among those treated with the thrice-a-day method than with the twice-a-day method. Time above MIC for administration at irregular time intervals was similar to that for q8h administration. Conclusions: Our administration method appears to be the most suitable for FN patients. With this method, late night and early morning drip infusion as well as the inconvenience of maintaining exact 8 h intervals can be avoided." @default.
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- W2137153134 date "2008-12-01" @default.
- W2137153134 modified "2023-09-30" @default.
- W2137153134 title "Optimal Administration Method of Cefepime for Febrile Neutropenia Based on Pharmacokinetic and Pharmacodynamic Findings" @default.
- W2137153134 doi "https://doi.org/10.1016/j.ijid.2008.05.269" @default.
- W2137153134 hasPublicationYear "2008" @default.
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