FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137156645> ?p ?o ?g. }

• W2137156645 endingPage "346" @default.
• W2137156645 startingPage "332" @default.
• W2137156645 abstract "Protein interaction networks play central roles in biological systems, from simple metabolic pathways through complex programs permitting the development of organisms. Multicellularity could only have arisen from a careful orchestration of cellular and molecular roles and responsibilities, all properly controlled and regulated. Disease reflects a breakdown of this organismal homeostasis. To better understand the evolution of interactions whose dysfunction may be contributing factors to disease, we derived the human protein coevolution network using our MatrixMatchMaker algorithm and using the Orthologous MAtrix project (OMA) database as a source for protein orthologs from 103 eukaryotic genomes. We annotated the coevolution network using protein–protein interaction data, many functional data sources, and we explored the evolutionary rates and dates of emergence of the proteins in our data set. Strikingly, clustering based only on the topology of the coevolution network partitions it into two subnetworks, one generally representing ancient eukaryotic functions and the other functions more recently acquired during animal evolution. That latter subnetwork is enriched for proteins with roles in cell–cell communication, the control of cell division, and related multicellular functions. Further annotation using data from genetic disease databases and cancer genome sequences strongly implicates these proteins in both ciliopathies and cancer. The enrichment for such disease markers in the animal network suggests a functional link between these coevolving proteins. Genetic validation corroborates the recruitment of ancient cilia in the evolution of multicellularity." @default.
• W2137156645 created "2016-06-24" @default.
• W2137156645 creator A5015161877 @default.
• W2137156645 creator A5028639003 @default.
• W2137156645 creator A5044497521 @default.
• W2137156645 creator A5046994281 @default.
• W2137156645 creator A5077733075 @default.
• W2137156645 date "2012-09-12" @default.
• W2137156645 modified "2023-10-16" @default.
• W2137156645 title "Coevolution Reveals a Network of Human Proteins Originating with Multicellularity" @default.
• W2137156645 cites W1970236704 @default.
• W2137156645 cites W1970357458 @default.
• W2137156645 cites W1976109148 @default.
• W2137156645 cites W1977120293 @default.
• W2137156645 cites W1987529702 @default.
• W2137156645 cites W1988632377 @default.
• W2137156645 cites W1994803330 @default.
• W2137156645 cites W1995449365 @default.
• W2137156645 cites W2003383185 @default.
• W2137156645 cites W2003567202 @default.
• W2137156645 cites W2004449991 @default.
• W2137156645 cites W2006944413 @default.
• W2137156645 cites W202972688 @default.
• W2137156645 cites W2031984159 @default.
• W2137156645 cites W2033799985 @default.
• W2137156645 cites W2034665038 @default.
• W2137156645 cites W2034950225 @default.
• W2137156645 cites W2037601806 @default.
• W2137156645 cites W2040108983 @default.
• W2137156645 cites W2044496115 @default.
• W2137156645 cites W2047078034 @default.
• W2137156645 cites W2048448217 @default.
• W2137156645 cites W2066480724 @default.
• W2137156645 cites W2073094091 @default.
• W2137156645 cites W2077266233 @default.
• W2137156645 cites W2100416170 @default.
• W2137156645 cites W2101266961 @default.
• W2137156645 cites W2101669461 @default.
• W2137156645 cites W2103970959 @default.
• W2137156645 cites W2113283367 @default.
• W2137156645 cites W2116145684 @default.
• W2137156645 cites W2118800699 @default.
• W2137156645 cites W2119362018 @default.
• W2137156645 cites W2120024428 @default.
• W2137156645 cites W2120800350 @default.
• W2137156645 cites W2123696077 @default.
• W2137156645 cites W2124567458 @default.
• W2137156645 cites W2127628411 @default.
• W2137156645 cites W2128036243 @default.
• W2137156645 cites W2132022258 @default.
• W2137156645 cites W2132120234 @default.
• W2137156645 cites W2136373330 @default.
• W2137156645 cites W2141640690 @default.
• W2137156645 cites W2143892509 @default.
• W2137156645 cites W2144907278 @default.
• W2137156645 cites W2152336513 @default.
• W2137156645 cites W2152568394 @default.
• W2137156645 cites W2158241520 @default.
• W2137156645 cites W2159675211 @default.
• W2137156645 cites W2164998314 @default.
• W2137156645 cites W2165525812 @default.
• W2137156645 cites W2407408969 @default.
• W2137156645 doi "https://doi.org/10.1093/molbev/mss218" @default.
• W2137156645 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3548307" @default.
• W2137156645 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22977115" @default.
• W2137156645 hasPublicationYear "2012" @default.
• W2137156645 type Work @default.
• W2137156645 sameAs 2137156645 @default.
• W2137156645 citedByCount "22" @default.
• W2137156645 countsByYear W21371566452013 @default.
• W2137156645 countsByYear W21371566452014 @default.
• W2137156645 countsByYear W21371566452015 @default.
• W2137156645 countsByYear W21371566452016 @default.
• W2137156645 countsByYear W21371566452017 @default.
• W2137156645 countsByYear W21371566452019 @default.
• W2137156645 countsByYear W21371566452020 @default.
• W2137156645 countsByYear W21371566452022 @default.
• W2137156645 countsByYear W21371566452023 @default.
• W2137156645 crossrefType "journal-article" @default.
• W2137156645 hasAuthorship W2137156645A5015161877 @default.
• W2137156645 hasAuthorship W2137156645A5028639003 @default.
• W2137156645 hasAuthorship W2137156645A5044497521 @default.
• W2137156645 hasAuthorship W2137156645A5046994281 @default.
• W2137156645 hasAuthorship W2137156645A5077733075 @default.
• W2137156645 hasBestOaLocation W21371566451 @default.
• W2137156645 hasConcept C104317684 @default.
• W2137156645 hasConcept C127716648 @default.
• W2137156645 hasConcept C141231307 @default.
• W2137156645 hasConcept C2910395002 @default.
• W2137156645 hasConcept C33009525 @default.
• W2137156645 hasConcept C54355233 @default.
• W2137156645 hasConcept C70721500 @default.
• W2137156645 hasConcept C74318829 @default.
• W2137156645 hasConcept C78458016 @default.
• W2137156645 hasConcept C86803240 @default.
• W2137156645 hasConceptScore W2137156645C104317684 @default.
• W2137156645 hasConceptScore W2137156645C127716648 @default.
• W2137156645 hasConceptScore W2137156645C141231307 @default.

• next