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• W2137162246 startingPage "1106" @default.
• W2137162246 abstract "Human herpesvirus 6B (HHV-6B) induces significant accumulation of p53 in both the nucleus and cytoplasm during infection. Activation of p53 by DNA damage is known to induce either growth arrest or apoptosis; nevertheless, HHV-6B-infected cells are arrested in their cell cycle independently of p53, and only a minor fraction of the infected cells undergoes apoptosis. Using pifithrin- α , a p53 inhibitor, and p53-null cells, this study showed that infected epithelial cells accumulated viral transcripts and proteins to a significantly higher degree in the absence of active p53. Moreover, HHV-6B-induced cytopathic effects were greatly enhanced in the absence of p53. This suggests that, in epithelial cells, some of the functions of p53 leading to cell-cycle arrest and apoptosis are restrained by HHV-6B infection, whereas other cellular defences, causing inhibition of virus transcription, are partially retained." @default.
• W2137162246 created "2016-06-24" @default.
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• W2137162246 date "2008-05-01" @default.
• W2137162246 modified "2023-10-14" @default.
• W2137162246 title "Restriction of human herpesvirus 6B replication by p53" @default.
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• W2137162246 doi "https://doi.org/10.1099/vir.0.83262-0" @default.
• W2137162246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18420787" @default.
• W2137162246 hasPublicationYear "2008" @default.
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