FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137164780> ?p ?o ?g. }

• W2137164780 endingPage "1418" @default.
• W2137164780 startingPage "1409" @default.
• W2137164780 abstract "Abstract The yeast Hsp110 chaperone Sse1 is a conserved protein that is a noncanonical member of the Hsp70 protein superfamily. Sse1 influences the cellular response to heat stress and has also been implicated in playing a role in the propagation of prions in yeast. Sse1 can seemingly exert its effects in vivo through direct or indirect actions by influencing the nucleotide exchange activity of canonical cytosolic Hsp70s. Using a genetic screen based on the inability to propagate the yeast [PSI+] prion, we have identified 13 new Sse1 mutants that are predicted to alter chaperone function through a variety of different mechanisms. Not only are these new Sse1 mutants altered in the ability to propagate and cure yeast prions but also to varying degrees in the ability to grow at elevated temperatures. The expression levels of chaperone proteins known to influence yeast prion propagation are unaltered in the Sse1 mutants, suggesting that the observed phenotypic effects are caused by direct functional alterations in these mutants. Mapping the location of the mutants onto the Sse1 crystal structure suggests that more than one functional alteration in Sse1 may result in changes in prion propagation and ability to function at elevated temperatures. All Sse1 mutants isolated provide essential functions in the cell under normal growth conditions, further demonstrating that essential chaperone functions in vivo can to some degree at least be detached from those related to propagation of prions. Our results suggest that Sse1 can influence prion propagation through a variety of different mechanisms." @default.
• W2137164780 created "2016-06-24" @default.
• W2137164780 creator A5056425573 @default.
• W2137164780 creator A5058049092 @default.
• W2137164780 creator A5065847905 @default.
• W2137164780 creator A5080352552 @default.
• W2137164780 creator A5081987606 @default.
• W2137164780 date "2013-08-01" @default.
• W2137164780 modified "2023-10-11" @default.
• W2137164780 title "Mutational Analysis of Sse1 (Hsp110) Suggests an Integral Role for this Chaperone in Yeast Prion Propagation<i>In Vivo</i>" @default.
• W2137164780 cites W1519473557 @default.
• W2137164780 cites W1959062138 @default.
• W2137164780 cites W1965142941 @default.
• W2137164780 cites W1972110853 @default.
• W2137164780 cites W1975836330 @default.
• W2137164780 cites W1991569028 @default.
• W2137164780 cites W2000204824 @default.
• W2137164780 cites W2000534539 @default.
• W2137164780 cites W2006743236 @default.
• W2137164780 cites W2013110945 @default.
• W2137164780 cites W2016983199 @default.
• W2137164780 cites W2020140985 @default.
• W2137164780 cites W2022498345 @default.
• W2137164780 cites W2028705478 @default.
• W2137164780 cites W2031652657 @default.
• W2137164780 cites W2033109626 @default.
• W2137164780 cites W2035353879 @default.
• W2137164780 cites W2043676526 @default.
• W2137164780 cites W2046413244 @default.
• W2137164780 cites W2046445620 @default.
• W2137164780 cites W2046603119 @default.
• W2137164780 cites W2047477750 @default.
• W2137164780 cites W2052854413 @default.
• W2137164780 cites W2055993297 @default.
• W2137164780 cites W2056649260 @default.
• W2137164780 cites W2064292796 @default.
• W2137164780 cites W2069300624 @default.
• W2137164780 cites W2077790507 @default.
• W2137164780 cites W2079572125 @default.
• W2137164780 cites W2080862490 @default.
• W2137164780 cites W2087296147 @default.
• W2137164780 cites W2089400513 @default.
• W2137164780 cites W2091512138 @default.
• W2137164780 cites W2094271177 @default.
• W2137164780 cites W2097772334 @default.
• W2137164780 cites W2099817168 @default.
• W2137164780 cites W2103725642 @default.
• W2137164780 cites W2113383822 @default.
• W2137164780 cites W2118878821 @default.
• W2137164780 cites W2119651404 @default.
• W2137164780 cites W2125465720 @default.
• W2137164780 cites W2128352699 @default.
• W2137164780 cites W2134124061 @default.
• W2137164780 cites W2137530170 @default.
• W2137164780 cites W2147770635 @default.
• W2137164780 cites W2153019640 @default.
• W2137164780 cites W2154290102 @default.
• W2137164780 cites W2156692055 @default.
• W2137164780 cites W2157355956 @default.
• W2137164780 cites W2159093521 @default.
• W2137164780 cites W2162930176 @default.
• W2137164780 cites W2164018178 @default.
• W2137164780 cites W2167826437 @default.
• W2137164780 cites W2168373973 @default.
• W2137164780 cites W2169333620 @default.
• W2137164780 doi "https://doi.org/10.1534/g3.113.007112" @default.
• W2137164780 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3737180" @default.
• W2137164780 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23797105" @default.
• W2137164780 hasPublicationYear "2013" @default.
• W2137164780 type Work @default.
• W2137164780 sameAs 2137164780 @default.
• W2137164780 citedByCount "13" @default.
• W2137164780 countsByYear W21371647802013 @default.
• W2137164780 countsByYear W21371647802014 @default.
• W2137164780 countsByYear W21371647802015 @default.
• W2137164780 countsByYear W21371647802016 @default.
• W2137164780 countsByYear W21371647802017 @default.
• W2137164780 countsByYear W21371647802021 @default.
• W2137164780 countsByYear W21371647802023 @default.
• W2137164780 crossrefType "journal-article" @default.
• W2137164780 hasAuthorship W2137164780A5056425573 @default.
• W2137164780 hasAuthorship W2137164780A5058049092 @default.
• W2137164780 hasAuthorship W2137164780A5065847905 @default.
• W2137164780 hasAuthorship W2137164780A5080352552 @default.
• W2137164780 hasAuthorship W2137164780A5081987606 @default.
• W2137164780 hasBestOaLocation W21371647801 @default.
• W2137164780 hasConcept C104317684 @default.
• W2137164780 hasConcept C127716648 @default.
• W2137164780 hasConcept C142724271 @default.
• W2137164780 hasConcept C143065580 @default.
• W2137164780 hasConcept C207001950 @default.
• W2137164780 hasConcept C2775962898 @default.
• W2137164780 hasConcept C2777576037 @default.
• W2137164780 hasConcept C2779222958 @default.
• W2137164780 hasConcept C54355233 @default.
• W2137164780 hasConcept C71924100 @default.
• W2137164780 hasConcept C86803240 @default.
• W2137164780 hasConcept C95444343 @default.

• next