Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137171484> ?p ?o ?g. }
- W2137171484 endingPage "304" @default.
- W2137171484 startingPage "293" @default.
- W2137171484 abstract "We have created a set of P-element excision-derived Gpdh alleles that generate a range of GPDH activity phenotypes ranging from zero to full activity. By placing these synthetic alleles in isogenic backgrounds, we characterize the effects of minor and major activity variation on two different aspects of Gpdh function: the standing triglyceride pool and glycerol-3-phosphate shuttle-assisted flight. We observe small but statistically significant reductions in triglyceride content for adult Gpdh genotypes possessing 33-80% reductions from normal activity. These small differences scale to a notable proportion of the observed genetic variation in triglyceride content in natural populations. Using a tethered fly assay to assess flight metabolism, we observed that genotypes with 100 and 66% activity exhibited no significant difference in wing-beat frequency (WBF), while activity reductions from 60 to 10% showed statistically significant reductions of approximately 7% in WBF. These studies show that the molecular polymorphism associated with GPDH activity could be maintained in natural populations by selection in the triglyceride pool." @default.
- W2137171484 created "2016-06-24" @default.
- W2137171484 creator A5021174211 @default.
- W2137171484 creator A5037299217 @default.
- W2137171484 creator A5060495478 @default.
- W2137171484 creator A5077374897 @default.
- W2137171484 date "2006-01-01" @default.
- W2137171484 modified "2023-09-25" @default.
- W2137171484 title "Triglyceride Pools, Flight and Activity Variation at the <i>Gpdh</i> Locus in <i>Drosophila melanogaster</i>" @default.
- W2137171484 cites W1511892231 @default.
- W2137171484 cites W1858387203 @default.
- W2137171484 cites W1930124070 @default.
- W2137171484 cites W1950166331 @default.
- W2137171484 cites W1954202468 @default.
- W2137171484 cites W1963784009 @default.
- W2137171484 cites W1965322903 @default.
- W2137171484 cites W1976030852 @default.
- W2137171484 cites W1983593184 @default.
- W2137171484 cites W1983852242 @default.
- W2137171484 cites W1987277384 @default.
- W2137171484 cites W1998661900 @default.
- W2137171484 cites W2002210062 @default.
- W2137171484 cites W2003866262 @default.
- W2137171484 cites W2010049282 @default.
- W2137171484 cites W2013881103 @default.
- W2137171484 cites W2018837783 @default.
- W2137171484 cites W2022897013 @default.
- W2137171484 cites W2035112094 @default.
- W2137171484 cites W2041769758 @default.
- W2137171484 cites W2049150449 @default.
- W2137171484 cites W2050698686 @default.
- W2137171484 cites W2052917167 @default.
- W2137171484 cites W2065315896 @default.
- W2137171484 cites W2080539420 @default.
- W2137171484 cites W2090230382 @default.
- W2137171484 cites W2094202031 @default.
- W2137171484 cites W2099602541 @default.
- W2137171484 cites W2102582209 @default.
- W2137171484 cites W2110705025 @default.
- W2137171484 cites W2111513185 @default.
- W2137171484 cites W2112310510 @default.
- W2137171484 cites W2112397251 @default.
- W2137171484 cites W2114086633 @default.
- W2137171484 cites W2127042925 @default.
- W2137171484 cites W2130223825 @default.
- W2137171484 cites W2133917963 @default.
- W2137171484 cites W2140176309 @default.
- W2137171484 cites W2144713660 @default.
- W2137171484 cites W2150052811 @default.
- W2137171484 cites W2150566147 @default.
- W2137171484 cites W2152012061 @default.
- W2137171484 cites W2155783580 @default.
- W2137171484 cites W2155866859 @default.
- W2137171484 cites W2171068240 @default.
- W2137171484 cites W2171811478 @default.
- W2137171484 cites W2179885821 @default.
- W2137171484 cites W2264019790 @default.
- W2137171484 cites W2314073991 @default.
- W2137171484 cites W2314456113 @default.
- W2137171484 cites W2322080139 @default.
- W2137171484 cites W2322918162 @default.
- W2137171484 cites W2324191770 @default.
- W2137171484 cites W2324398555 @default.
- W2137171484 cites W2334419324 @default.
- W2137171484 cites W2397491771 @default.
- W2137171484 cites W334088060 @default.
- W2137171484 cites W4251885051 @default.
- W2137171484 cites W4323517649 @default.
- W2137171484 doi "https://doi.org/10.1534/genetics.105.047035" @default.
- W2137171484 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1456158" @default.
- W2137171484 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16204217" @default.
- W2137171484 hasPublicationYear "2006" @default.
- W2137171484 type Work @default.
- W2137171484 sameAs 2137171484 @default.
- W2137171484 citedByCount "34" @default.
- W2137171484 countsByYear W21371714842012 @default.
- W2137171484 countsByYear W21371714842015 @default.
- W2137171484 countsByYear W21371714842016 @default.
- W2137171484 countsByYear W21371714842017 @default.
- W2137171484 countsByYear W21371714842018 @default.
- W2137171484 countsByYear W21371714842019 @default.
- W2137171484 countsByYear W21371714842021 @default.
- W2137171484 countsByYear W21371714842022 @default.
- W2137171484 countsByYear W21371714842023 @default.
- W2137171484 crossrefType "journal-article" @default.
- W2137171484 hasAuthorship W2137171484A5021174211 @default.
- W2137171484 hasAuthorship W2137171484A5037299217 @default.
- W2137171484 hasAuthorship W2137171484A5060495478 @default.
- W2137171484 hasAuthorship W2137171484A5077374897 @default.
- W2137171484 hasBestOaLocation W21371714841 @default.
- W2137171484 hasConcept C104317684 @default.
- W2137171484 hasConcept C127716648 @default.
- W2137171484 hasConcept C135763542 @default.
- W2137171484 hasConcept C153471976 @default.
- W2137171484 hasConcept C180754005 @default.
- W2137171484 hasConcept C2778163477 @default.
- W2137171484 hasConcept C2778913445 @default.
- W2137171484 hasConcept C2780104201 @default.