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• W2137174865 startingPage "7236" @default.
• W2137174865 abstract "Quinones and quinoproteins are essential redox components and enzymes in biological systems. Here, we report the de novo design, synthesis, and properties of model four-α-helix bundle quinoproteins. The proteins were designed and constructed from three different helices with 21 or 22 amino acid residues by chemoselective ligation to a cyclic decapeptide template. A free cysteine unit is placed at the hydrophobic core of the protein for binding of ubiquinone-0 and menaquinone-0 through a thioether bond. The quinoproteins with molecular weights of 11–12 kDa were characterized by electrospray ionization mass spectrometry, UV/Vis spectroscopy, size-exclusion chromatography, circular dichroism measurements, 1H NMR spectroscopy, cyclic voltammetry, and redox-induced FTIR difference spectroscopy. The midpoint redox potentials at pH 8 in aqueous solution Em,8 of thioether conjugates with N-acetyl cysteine methyl ester were 89 mV and −63 mV and with a synthetic protein 229 mV and 249 mV versus standard hydrogen electrode (SHE) for ubiquinone-0 and menaquinone-0, respectively. Detailed redox-induced FTIR difference spectroscopic studies of the model compounds and quinoproteins show the special resonance features for CO bands at 1656–1660 and 1655–1665 cm−1 due to the sulfur substitution to ubiquinone-0 and menaquinone-0, respectively. The construction of model quinoproteins represents a significant step toward more complex artificial redox systems." @default.
• W2137174865 created "2016-06-24" @default.
• W2137174865 creator A5000422071 @default.
• W2137174865 creator A5000775059 @default.
• W2137174865 creator A5005030141 @default.
• W2137174865 creator A5060411899 @default.
• W2137174865 date "2006-09-18" @default.
• W2137174865 modified "2023-10-18" @default.
• W2137174865 title "De Novo Design, Synthesis, and Characterization of Quinoproteins" @default.
• W2137174865 cites W104268342 @default.
• W2137174865 cites W1499265968 @default.
• W2137174865 cites W1524781921 @default.
• W2137174865 cites W1529096289 @default.
• W2137174865 cites W1533540035 @default.
• W2137174865 cites W1541197218 @default.
• W2137174865 cites W1563988826 @default.
• W2137174865 cites W1566080486 @default.
• W2137174865 cites W1747345588 @default.
• W2137174865 cites W1920829488 @default.
• W2137174865 cites W1969848980 @default.
• W2137174865 cites W1974259086 @default.
• W2137174865 cites W1976019788 @default.
• W2137174865 cites W1978046058 @default.
• W2137174865 cites W1982340399 @default.
• W2137174865 cites W1983435629 @default.
• W2137174865 cites W1989452309 @default.
• W2137174865 cites W1991964301 @default.
• W2137174865 cites W1995218611 @default.
• W2137174865 cites W1997043096 @default.
• W2137174865 cites W2002602060 @default.
• W2137174865 cites W2005170066 @default.
• W2137174865 cites W2005223886 @default.
• W2137174865 cites W2009379756 @default.
• W2137174865 cites W2013037193 @default.
• W2137174865 cites W2019137326 @default.
• W2137174865 cites W2021132163 @default.
• W2137174865 cites W2021184936 @default.
• W2137174865 cites W2027640067 @default.
• W2137174865 cites W2031587301 @default.
• W2137174865 cites W2033993127 @default.
• W2137174865 cites W2040490477 @default.
• W2137174865 cites W2046178428 @default.
• W2137174865 cites W2046301311 @default.
• W2137174865 cites W2050895939 @default.
• W2137174865 cites W2051432952 @default.
• W2137174865 cites W2059919577 @default.
• W2137174865 cites W2061635186 @default.
• W2137174865 cites W2063177251 @default.
• W2137174865 cites W2064499093 @default.
• W2137174865 cites W2065382671 @default.
• W2137174865 cites W2070493796 @default.
• W2137174865 cites W2070783618 @default.
• W2137174865 cites W2071059615 @default.
• W2137174865 cites W2072628378 @default.
• W2137174865 cites W2073973503 @default.
• W2137174865 cites W2075610370 @default.
• W2137174865 cites W2076912752 @default.
• W2137174865 cites W2077514239 @default.
• W2137174865 cites W2086317499 @default.
• W2137174865 cites W2089638668 @default.
• W2137174865 cites W2090219627 @default.
• W2137174865 cites W2090383817 @default.
• W2137174865 cites W2092102609 @default.
• W2137174865 cites W2093468577 @default.
• W2137174865 cites W2098918432 @default.
• W2137174865 cites W2103008129 @default.
• W2137174865 cites W2103876040 @default.
• W2137174865 cites W2104216711 @default.
• W2137174865 cites W2104460080 @default.
• W2137174865 cites W2120601381 @default.
• W2137174865 cites W2142510840 @default.
• W2137174865 cites W2145237386 @default.
• W2137174865 cites W2148984477 @default.
• W2137174865 cites W2149178975 @default.
• W2137174865 cites W2152893715 @default.
• W2137174865 cites W2161214077 @default.
• W2137174865 cites W2161573757 @default.
• W2137174865 cites W2162659597 @default.
• W2137174865 cites W2314212185 @default.
• W2137174865 cites W2326159525 @default.
• W2137174865 cites W2410137063 @default.
• W2137174865 cites W267757020 @default.
• W2137174865 cites W4253824871 @default.
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• W2137174865 doi "https://doi.org/10.1002/chem.200501212" @default.
• W2137174865 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16819733" @default.
• W2137174865 hasPublicationYear "2006" @default.
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