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- W2137176719 abstract "Calcitonin gene-related peptide (CGRP) is the most potent endogenous vasodilator peptide known to date (1–4). There are two forms of CGRP, α and β, which differ in only two amino acids in rats and three in humans. α-CGRP is derived from the tissuespecific splicing of the calcitonin/CGRP gene. Whereas calcitonin is produced mainly in the C cells of the thyroid, CGRP synthesis is limited almost exclusively to specific regions of the central and peripheral nervous systems. The β-CGRP gene that is located on the same chromosome as the calcitonin/α-CGRP gene does not produce calcitonin and is also synthesized primarily in neuronal tissues. α-CGRP is prevalent in the central nervous system and in the peripheral sensory neural network. β-CGRP is also prevalent in the central nervous system, but peripherally is common in intestinal neurons (1–5). However, the biological activities of both peptides are similar in most vascular beds." @default.
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- W2137176719 date "2007-01-01" @default.
- W2137176719 modified "2023-09-23" @default.
- W2137176719 title "Calcitonin Gene-Related Peptide and Hypertension" @default.
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- W2137176719 doi "https://doi.org/10.1007/978-1-59259-987-5_9" @default.
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