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- W2137179640 abstract "Progesterone-induced meiotic maturation of Xenopus oocytes requires the synthesis of new proteins, such as Mos and cyclin B. Synthesis of Mos is thought to be necessary and sufficient for meiotic maturation; however, it has recently been proposed that newly synthesized proteins binding to p34(cdc2) could be involved in a signaling pathway that triggers the activation of maturation-promoting factor. We focused our attention on cyclin B proteins because they are synthesized in response to progesterone, they bind to p34(cdc2), and their microinjection into resting oocytes induces meiotic maturation. We investigated cyclin B accumulation in response to progesterone in the absence of maturation-promoting factor-induced feedback. We report here that the cdk inhibitor p21(cip1), when microinjected into immature Xenopus oocytes, blocks germinal vesicle breakdown induced by progesterone, by maturation-promoting factor transfer, or by injection of okadaic acid. After microinjection of p21(cip1), progesterone fails to induce the activation of MAPK or p34(cdc2), and Mos does not accumulate. In contrast, the level of cyclin B1 increases normally in a manner dependent on down-regulation of cAMP-dependent protein kinase but independent of cap-ribose methylation of mRNA." @default.
- W2137179640 created "2016-06-24" @default.
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- W2137179640 date "1999-10-01" @default.
- W2137179640 modified "2023-09-29" @default.
- W2137179640 title "Two Distinct Mechanisms Control the Accumulation of Cyclin B1 and Mos in<i>Xenopus</i>Oocytes in Response to Progesterone" @default.
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- W2137179640 doi "https://doi.org/10.1091/mbc.10.10.3279" @default.
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