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- W2137181202 startingPage "e1002000" @default.
- W2137181202 abstract "Expansion of the neocortex is a hallmark of human evolution. However, it remains an open question what adaptive mechanisms facilitated its expansion. Here we show, using gyrencephaly index (GI) and other physiological and life-history data for 102 mammalian species, that gyrencephaly is an ancestral mammalian trait. We provide evidence that the evolution of a highly folded neocortex, as observed in humans, requires the traversal of a threshold of 10^9 neurons, and that species above and below the threshold exhibit a bimodal distribution of physiological and life-history traits, establishing two phenotypic groups. We identify, using discrete mathematical models, proliferative divisions of progenitors in the basal compartment of the developing neocortex as evolutionarily necessary and sufficient for generating a fourteen-fold increase in daily prenatal neuron production and thus traversal of the neuronal threshold. We demonstrate that length of neurogenic period, rather than any novel progenitor-type, is sufficient to distinguish cortical neuron number between species within the same phenotypic group." @default.
- W2137181202 created "2016-06-24" @default.
- W2137181202 creator A5027036729 @default.
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- W2137181202 creator A5042671050 @default.
- W2137181202 creator A5061342418 @default.
- W2137181202 creator A5066735581 @default.
- W2137181202 date "2014-11-18" @default.
- W2137181202 modified "2023-10-17" @default.
- W2137181202 title "An Adaptive Threshold in Mammalian Neocortical Evolution" @default.
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