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• W2137181625 startingPage "89" @default.
• W2137181625 abstract "Sex-specific alternative RNA splicing of the doublesex (dsx) pre-mRNA results in sex-specific polypeptides that regulate both male and female somatic sexual differentiation in Drosophila melanogaster. We have molecularly characterized a class of dsx mutations that act in cis to disrupt the regulation of dsx RNA processing, causing the dsx pre-mRNA to be spliced in the male-specific pattern regardless of the chromosomal sex of the fly. These dsx mutations are associated with rearrangements in the female-specific exon just 3' to the female-specific splice acceptor. The mutations do not affect the female-specific splice sites or intron that are identical to wild-type sequences. These results indicate that sequences in the female-specific exon are important for the regulation of sex-specific RNA splicing, perhaps by acting as sites of interaction with trans-acting regulators. Furthermore, the data suggest that female-specific regulation of dsx RNA processing occurs by promoting the usage of the female splice acceptor site, rather than by repressing the usage of the alternative male-specific splice acceptor." @default.
• W2137181625 created "2016-06-24" @default.
• W2137181625 creator A5006940807 @default.
• W2137181625 creator A5034697387 @default.
• W2137181625 date "1990-01-01" @default.
• W2137181625 modified "2023-09-25" @default.
• W2137181625 title "Regulation of sex-specific RNA splicing at the Drosophila doublesex gene: cis-acting mutations in exon sequences alter sex-specific RNA splicing patterns." @default.
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• W2137181625 doi "https://doi.org/10.1101/gad.4.1.89" @default.
• W2137181625 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2155161" @default.
• W2137181625 hasPublicationYear "1990" @default.
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