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• W2137188823 abstract "Human autoimmune gastritis (AIG) is a chronic inflammatory disorder of the gastric corpus. We have defined the antigen repertoire and the functional properties of in vivo activated CD4+ T cells derived from the gastric mucosa of patients with AIG. A remarkable proportion of the CD4+ T cell clones proliferated in response to H+,K+-ATPase. Six epitopes identified in the alpha chain, and 5 in the beta chain, of gastric K+,K+-ATPase were recognized by autoreactive gastric T cell clones. The majority of the autoreactive T cell clones secreted IFN-gamma and showed a T helper 1 (Th1) profile. All clones produced TNF-alpha,provided help for B cell immunoglobulin production, expressed perforin-mediated cytotoxicity, and most induced Fas-Fas ligand-mediated apoptosis. Data suggest that activation of gastric H+,K+-ATPase-specific Th1 T cells is crucial in the pathogenesis of human gastric autoimmunity and atrophy." @default.
• W2137188823 created "2016-06-24" @default.
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• W2137188823 date "2005-01-01" @default.
• W2137188823 modified "2023-10-16" @default.
• W2137188823 title "Molecular Specificity and Functional Properties of Autoreactive T-Cell Response in Human Gastric Autoimmunity" @default.
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• W2137188823 doi "https://doi.org/10.1080/08830180590884611" @default.
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