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• W2137190788 endingPage "602" @default.
• W2137190788 startingPage "597" @default.
• W2137190788 abstract "The myelin-associated glycoprotein (MAG) was quantitated in the CNS and PNS of quaking mice and the levels compared to the levels of myelin basic protein (MBP) and 2':3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) activity. In the brainstems of 36-day-old quaking mice, MBP, MAG, and CNPase were reduced to 12, 16, and 29% of control levels, respectively. In the sciatic nerves of the 36-day-old quaking mice, MBP and CNPase were 38 and 75% of control levels, respectively, whereas the concentration of MAG was unchanged or slightly increased. Similar quantitative results were obtained for the sciatic nerves and spinal roots of 7-month-old quaking mice. Immunoblots showed that the principal MAG band from the brainstems, sciatic nerves, and spinal roots of the quaking mice had a higher than normal apparent Mr. In addition, there was a minor component reacting with anti-MAG antiserum in the brainstems of the quaking mice that had a slightly lower Mr than control MAG and was not detected in the normal mice. The results for the quaking mice are compared with those from similar studies on other mutants with dysmyelination of the CNS and PNS." @default.
• W2137190788 created "2016-06-24" @default.
• W2137190788 creator A5030347733 @default.
• W2137190788 creator A5063443996 @default.
• W2137190788 creator A5064025316 @default.
• W2137190788 date "1987-08-01" @default.
• W2137190788 modified "2023-09-23" @default.
• W2137190788 title "Myelin-Associated Glycoprotein in the Central and Peripheral Nervous System of Quaking Mice" @default.
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• W2137190788 doi "https://doi.org/10.1111/j.1471-4159.1987.tb02905.x" @default.
• W2137190788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2439656" @default.
• W2137190788 hasPublicationYear "1987" @default.
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