Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137199638> ?p ?o ?g. }
- W2137199638 endingPage "326" @default.
- W2137199638 startingPage "320" @default.
- W2137199638 abstract "TrxG and PcG complexes play key roles in the epigenetic regulation of development through H3K4me3 and H3K27me3 modification at specific sites throughout the human genome, but how these sites are selected is poorly understood. We find that in pluripotent cells, clustered CpG-islands at genes predict occupancy of H3K4me3 and H3K27me3, and these bivalent chromatin domains precisely span the boundaries of CpG-island clusters. These relationships are specific to pluripotent stem cells and are not retained at H3K4me3 and H3K27me3 sites unique to differentiated cells. We show that putative transcripts from clustered CpG-islands predict stem-loop structures characteristic of those bound by PcG complexes, consistent with the possibility that RNA facilitates PcG recruitment or maintenance at these sites. These studies suggest that CpG-island structure plays a fundamental role in establishing developmentally important chromatin structures in the pluripotent genome, and a subordinate role in establishing TrxG/PcG chromatin structure at sites unique to differentiated cells." @default.
- W2137199638 created "2016-06-24" @default.
- W2137199638 creator A5017332103 @default.
- W2137199638 creator A5048608729 @default.
- W2137199638 creator A5057814473 @default.
- W2137199638 creator A5089343289 @default.
- W2137199638 date "2012-11-01" @default.
- W2137199638 modified "2023-09-30" @default.
- W2137199638 title "CpG island structure and trithorax/polycomb chromatin domains in human cells" @default.
- W2137199638 cites W124269711 @default.
- W2137199638 cites W1543796220 @default.
- W2137199638 cites W1882476417 @default.
- W2137199638 cites W1968931043 @default.
- W2137199638 cites W1972170164 @default.
- W2137199638 cites W1973279069 @default.
- W2137199638 cites W1973549360 @default.
- W2137199638 cites W1974767234 @default.
- W2137199638 cites W1977943782 @default.
- W2137199638 cites W2000491188 @default.
- W2137199638 cites W2001730700 @default.
- W2137199638 cites W2006463715 @default.
- W2137199638 cites W2010291571 @default.
- W2137199638 cites W2011181841 @default.
- W2137199638 cites W2015416439 @default.
- W2137199638 cites W2016849135 @default.
- W2137199638 cites W2017840637 @default.
- W2137199638 cites W2027870104 @default.
- W2137199638 cites W2037686178 @default.
- W2137199638 cites W2040149948 @default.
- W2137199638 cites W2047574433 @default.
- W2137199638 cites W2051911149 @default.
- W2137199638 cites W2052741109 @default.
- W2137199638 cites W2053758959 @default.
- W2137199638 cites W2058673308 @default.
- W2137199638 cites W2059968749 @default.
- W2137199638 cites W2060608189 @default.
- W2137199638 cites W2072035127 @default.
- W2137199638 cites W2074324848 @default.
- W2137199638 cites W2084719919 @default.
- W2137199638 cites W2084748297 @default.
- W2137199638 cites W2085670913 @default.
- W2137199638 cites W2091151146 @default.
- W2137199638 cites W2099343472 @default.
- W2137199638 cites W2101177674 @default.
- W2137199638 cites W2103540918 @default.
- W2137199638 cites W2108078422 @default.
- W2137199638 cites W2115992869 @default.
- W2137199638 cites W2116236561 @default.
- W2137199638 cites W2118681186 @default.
- W2137199638 cites W2119885620 @default.
- W2137199638 cites W2120330019 @default.
- W2137199638 cites W2125669948 @default.
- W2137199638 cites W2126504590 @default.
- W2137199638 cites W2126973493 @default.
- W2137199638 cites W2130202009 @default.
- W2137199638 cites W2133452708 @default.
- W2137199638 cites W2133938268 @default.
- W2137199638 cites W2135229538 @default.
- W2137199638 cites W2144137532 @default.
- W2137199638 cites W2146573461 @default.
- W2137199638 cites W2149821525 @default.
- W2137199638 cites W2153424791 @default.
- W2137199638 cites W2154535417 @default.
- W2137199638 cites W2161399316 @default.
- W2137199638 cites W2169155700 @default.
- W2137199638 cites W2169416332 @default.
- W2137199638 cites W2242029997 @default.
- W2137199638 doi "https://doi.org/10.1016/j.ygeno.2012.07.006" @default.
- W2137199638 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3483364" @default.
- W2137199638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22819920" @default.
- W2137199638 hasPublicationYear "2012" @default.
- W2137199638 type Work @default.
- W2137199638 sameAs 2137199638 @default.
- W2137199638 citedByCount "37" @default.
- W2137199638 countsByYear W21371996382013 @default.
- W2137199638 countsByYear W21371996382014 @default.
- W2137199638 countsByYear W21371996382016 @default.
- W2137199638 countsByYear W21371996382017 @default.
- W2137199638 countsByYear W21371996382018 @default.
- W2137199638 countsByYear W21371996382019 @default.
- W2137199638 countsByYear W21371996382020 @default.
- W2137199638 countsByYear W21371996382021 @default.
- W2137199638 countsByYear W21371996382022 @default.
- W2137199638 countsByYear W21371996382023 @default.
- W2137199638 crossrefType "journal-article" @default.
- W2137199638 hasAuthorship W2137199638A5017332103 @default.
- W2137199638 hasAuthorship W2137199638A5048608729 @default.
- W2137199638 hasAuthorship W2137199638A5057814473 @default.
- W2137199638 hasAuthorship W2137199638A5089343289 @default.
- W2137199638 hasBestOaLocation W21371996382 @default.
- W2137199638 hasConcept C101762097 @default.
- W2137199638 hasConcept C104317684 @default.
- W2137199638 hasConcept C107459253 @default.
- W2137199638 hasConcept C137338518 @default.
- W2137199638 hasConcept C140173407 @default.
- W2137199638 hasConcept C141231307 @default.
- W2137199638 hasConcept C145103041 @default.
- W2137199638 hasConcept C150194340 @default.