FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137202581> ?p ?o ?g. }

• W2137202581 endingPage "10157" @default.
• W2137202581 startingPage "10152" @default.
• W2137202581 abstract "The secreted protein Sonic hedgehog (Shh) and its transmembrane receptor Patched (Ptc) control a major signal transduction pathway in early vertebrate limb development. Ligand-free Ptc interacts with the transmembrane protein Smoothened (Smo) and blocks expression of Smo-controlled genes including ptc . Ligand-bound Ptc removes the block and leads to further expression of ptc , which in turn restricts the range of Shh transport. Currently it is not certain that Shh functions as a morphogen on the 300-μm scale of early chick limb development, because it has been difficult to determine how far different forms of Shh are transported. We develop a model to study the effects of two forms of Shh used experimentally and propose a mechanism for Shh signal transduction based on a two-state model for the Ptc-Smo interaction. Recent bead- and tissue-implant experiments can be explained by using this model without postulating different diffusivities for the two forms of Shh; a difference in other parameters such as the rate of release of Shh from the bead or transplant can explain the results equally well. The model also predicts that lower concentrations of Shh in a bead will produce a response similar to that after a tissue transplant. Our results provide an explanation for the counterintuitive experimental results and show that the same signal transduction mechanism can explain both short- and long-range Shh signaling. We conclude that Shh can function as a long-range morphogen." @default.
• W2137202581 created "2016-06-24" @default.
• W2137202581 creator A5047421623 @default.
• W2137202581 creator A5054877460 @default.
• W2137202581 creator A5085304964 @default.
• W2137202581 date "2003-08-20" @default.
• W2137202581 modified "2023-10-17" @default.
• W2137202581 title "Short- and long-range effects of <i>Sonic hedgehog</i> in limb development" @default.
• W2137202581 cites W1565817365 @default.
• W2137202581 cites W1616421194 @default.
• W2137202581 cites W1831674169 @default.
• W2137202581 cites W1950282772 @default.
• W2137202581 cites W1968717680 @default.
• W2137202581 cites W1971136975 @default.
• W2137202581 cites W1976520395 @default.
• W2137202581 cites W1993416164 @default.
• W2137202581 cites W2022285707 @default.
• W2137202581 cites W2023611377 @default.
• W2137202581 cites W2037369918 @default.
• W2137202581 cites W2051807331 @default.
• W2137202581 cites W2055672003 @default.
• W2137202581 cites W2055792519 @default.
• W2137202581 cites W2059532513 @default.
• W2137202581 cites W2067761409 @default.
• W2137202581 cites W2077802746 @default.
• W2137202581 cites W2082968098 @default.
• W2137202581 cites W2086580927 @default.
• W2137202581 cites W2088068726 @default.
• W2137202581 cites W2093727998 @default.
• W2137202581 cites W2105505995 @default.
• W2137202581 cites W2106232134 @default.
• W2137202581 cites W2108707301 @default.
• W2137202581 cites W2109976541 @default.
• W2137202581 cites W2124424948 @default.
• W2137202581 cites W2157546970 @default.
• W2137202581 cites W2158483162 @default.
• W2137202581 cites W2163838718 @default.
• W2137202581 cites W2182792048 @default.
• W2137202581 cites W2304456343 @default.
• W2137202581 doi "https://doi.org/10.1073/pnas.1830500100" @default.
• W2137202581 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/193531" @default.
• W2137202581 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12930894" @default.
• W2137202581 hasPublicationYear "2003" @default.
• W2137202581 type Work @default.
• W2137202581 sameAs 2137202581 @default.
• W2137202581 citedByCount "57" @default.
• W2137202581 countsByYear W21372025812012 @default.
• W2137202581 countsByYear W21372025812013 @default.
• W2137202581 countsByYear W21372025812014 @default.
• W2137202581 countsByYear W21372025812015 @default.
• W2137202581 countsByYear W21372025812016 @default.
• W2137202581 countsByYear W21372025812018 @default.
• W2137202581 countsByYear W21372025812020 @default.
• W2137202581 countsByYear W21372025812021 @default.
• W2137202581 countsByYear W21372025812022 @default.
• W2137202581 countsByYear W21372025812023 @default.
• W2137202581 crossrefType "journal-article" @default.
• W2137202581 hasAuthorship W2137202581A5047421623 @default.
• W2137202581 hasAuthorship W2137202581A5054877460 @default.
• W2137202581 hasAuthorship W2137202581A5085304964 @default.
• W2137202581 hasBestOaLocation W21372025812 @default.
• W2137202581 hasConcept C104317684 @default.
• W2137202581 hasConcept C116569031 @default.
• W2137202581 hasConcept C145837895 @default.
• W2137202581 hasConcept C170493617 @default.
• W2137202581 hasConcept C185592680 @default.
• W2137202581 hasConcept C196843134 @default.
• W2137202581 hasConcept C24530287 @default.
• W2137202581 hasConcept C2776637008 @default.
• W2137202581 hasConcept C2777994357 @default.
• W2137202581 hasConcept C2778386714 @default.
• W2137202581 hasConcept C2778539099 @default.
• W2137202581 hasConcept C55493867 @default.
• W2137202581 hasConcept C62478195 @default.
• W2137202581 hasConcept C86370654 @default.
• W2137202581 hasConcept C86803240 @default.
• W2137202581 hasConcept C88498014 @default.
• W2137202581 hasConcept C95444343 @default.
• W2137202581 hasConceptScore W2137202581C104317684 @default.
• W2137202581 hasConceptScore W2137202581C116569031 @default.
• W2137202581 hasConceptScore W2137202581C145837895 @default.
• W2137202581 hasConceptScore W2137202581C170493617 @default.
• W2137202581 hasConceptScore W2137202581C185592680 @default.
• W2137202581 hasConceptScore W2137202581C196843134 @default.
• W2137202581 hasConceptScore W2137202581C24530287 @default.
• W2137202581 hasConceptScore W2137202581C2776637008 @default.
• W2137202581 hasConceptScore W2137202581C2777994357 @default.
• W2137202581 hasConceptScore W2137202581C2778386714 @default.
• W2137202581 hasConceptScore W2137202581C2778539099 @default.
• W2137202581 hasConceptScore W2137202581C55493867 @default.
• W2137202581 hasConceptScore W2137202581C62478195 @default.
• W2137202581 hasConceptScore W2137202581C86370654 @default.
• W2137202581 hasConceptScore W2137202581C86803240 @default.
• W2137202581 hasConceptScore W2137202581C88498014 @default.
• W2137202581 hasConceptScore W2137202581C95444343 @default.
• W2137202581 hasIssue "18" @default.
• W2137202581 hasLocation W21372025811 @default.
• W2137202581 hasLocation W21372025812 @default.

• next