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- W2137209191 endingPage "729" @default.
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- W2137209191 abstract "Genetic and environmental factors responsible for numerous neurodegenerative diseases vary between disorders, yet age remains a universal risk factor. Age-associated decline in protein homeostasis, or proteostasis, enables disease-linked proteins to adopt aberrant tertiary structures, accumulate as higher-ordered aggregates, and cause a myriad of cellular dysfunctions and neuronal death. However, recent findings suggest that the assembly of disease proteins into tightly ordered aggregates can significantly delay proteotoxic onset. Furthermore, manipulation of metabolic pathways through key signaling components extends lifespan, bolsters proteostasis networks, and delays the onset of proteotoxicity. Thus, understanding the relationship between proteostasis and aging has provided important insights into neurodegeneration." @default.
- W2137209191 created "2016-06-24" @default.
- W2137209191 creator A5015372011 @default.
- W2137209191 creator A5037467146 @default.
- W2137209191 date "2010-09-06" @default.
- W2137209191 modified "2023-10-14" @default.
- W2137209191 title "Protein homeostasis and aging in neurodegeneration" @default.
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