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- W2137218384 endingPage "34" @default.
- W2137218384 startingPage "19" @default.
- W2137218384 abstract "Since its introduction in 1960, the combined oral contraceptive (COC) pill has become one of the most widely and frequently used methods of contraception worldwide. Although highly effective, early COC formulations were associated with significant adverse effects and unacceptable cardiovascular risk. Improvements in tolerability and safety have been achieved, without compromises in effectiveness, primarily via hormone dosage reductions and the development of several new progestins. Multiphasic COCs and extended-/continuous-cycle COCs have also been introduced, although the clinical advantages of these formulations vs. traditional COCs have yet to be established. Inclusion of natural estrogens such as estradiol valerate and 17β-estradiol with selective progestins in new combinations that maintain good cycle control is the most recent evolutionary step designed to improve COC tolerability and safety. Vigorous research needs to continue to help guarantee that the unmet need for safe and effective contraception is satisfied in future generations." @default.
- W2137218384 created "2016-06-24" @default.
- W2137218384 creator A5003210365 @default.
- W2137218384 creator A5031550286 @default.
- W2137218384 creator A5077242876 @default.
- W2137218384 date "2011-07-01" @default.
- W2137218384 modified "2023-10-01" @default.
- W2137218384 title "The evolution of combined oral contraception: improving the risk-to-benefit ratio" @default.
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