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• W2137227311 startingPage "6953" @default.
• W2137227311 abstract "Nucleotide excision repair and translesion DNA synthesis are two processes that operate at arrested replication forks to reduce the frequency of recombination and promote cell survival following UV-induced DNA damage. While nucleotide excision repair is generally considered to be error free, translesion synthesis can result in mutations, making it important to identify the order and conditions that determine when each process is recruited to the arrested fork. We show here that at early times following UV irradiation, the recovery of DNA synthesis occurs through nucleotide excision repair of the lesion. In the absence of repair or when the repair capacity of the cell has been exceeded, translesion synthesis by polymerase V (Pol V) allows DNA synthesis to resume and is required to protect the arrested replication fork from degradation. Pol II and Pol IV do not contribute detectably to survival, mutagenesis, or restoration of DNA synthesis, suggesting that, in vivo, these polymerases are not functionally redundant with Pol V at UV-induced lesions. We discuss a model in which cells first use DNA repair to process replication-arresting UV lesions before resorting to mutagenic pathways such as translesion DNA synthesis to bypass these impediments to replication progression." @default.
• W2137227311 created "2016-06-24" @default.
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• W2137227311 date "2005-10-15" @default.
• W2137227311 modified "2023-10-02" @default.
• W2137227311 title "Nucleotide Excision Repair or Polymerase V-Mediated Lesion Bypass Can Act To Restore UV-Arrested Replication Forks in <i>Escherichia coli</i>" @default.
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• W2137227311 doi "https://doi.org/10.1128/jb.187.20.6953-6961.2005" @default.
• W2137227311 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1251618" @default.
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