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• W2137230236 abstract "The relationship between obesity and prostate cancer (CaP) treatment failure is complex and may vary by patient- and neighborhood-level educational attainment. We evaluated whether patient- and neighborhood-level education is associated with the effect of obesity on biochemical recurrence.Seven hundred and forty-six CaP cases were classified into four groups: Concordant Low-Low: less educated cases (<4 years college) living in a less educated neighborhood (below-median proportion of college-educated residents; n = 164); Concordant High-High: highly educated cases (≥ 4 years college) living in a highly educated neighborhood (above-median proportion of college-educated residents; n = 326); Discordant Low-High: less educated cases living in a highly educated neighborhood (n = 69); and Discordant High-Low: highly educated cases living in a less educated neighborhood (n = 187). Cox regression models were used to examine associations between obesity and biochemical (PSA) failure after prostatectomy stratified by the concordant/discordant groups.The association of obesity with biochemical failure varied significantly by educational concordance/discordance (p = 0.007). Obesity was associated with risk of biochemical failure for less educated cases residing in less educated neighborhoods (HR 3.72, 95% CI 1.30-10.65). The relationship was not significant for other concordant/discordant groups.Obesity effects on CaP outcomes vary by multilevel educational discordance/concordance. Strategies to decrease prostate cancer risk of progression may focus on reduction in obesity, particularly for less educated cases residing in less educated neighborhoods." @default.
• W2137230236 created "2016-06-24" @default.
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• W2137230236 date "2015-07-14" @default.
• W2137230236 modified "2023-09-23" @default.
• W2137230236 title "Individual- and neighborhood-level education influences the effect of obesity on prostate cancer treatment failure after prostatectomy" @default.
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• W2137230236 doi "https://doi.org/10.1007/s10552-015-0628-y" @default.
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