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• W2137240047 abstract "An estimated 10% of the American population has some degree of renal disease, although asymptomatic. In Brazil, no data are available on the prevalence of chronic renal d isease. A number of studies show a direct and close relationship between the degree of renal dysfunction and Cardiovascular Disease (CVD) risk. Th is increased CVD risk, despite being maximal in end-stage renal failu re, begins to be noticed with slight declines in renal function. In addition, the presence of renal in jury, even with normal renal function, evidenced by proteinuria or microalbu minuria, is also a potent CVD risk factor. At present, the primary causes of renal disease are diabetic nephropathy and hypertensive nephrosclerosis, accelerated by cigarette smo king and dyslipidemia. Hence, increased CVD risk in patients with chronic kidney disease may be secondary to the accumulation of these classical risk factors; however, frequency of CVD events in these patients is higher than that predicted by equations that take into account such classical factors. Therefore, there may be mechanis ms intrinsic to renal lesion capable of accelerating systemic atherosclerosis. Accordingly, uremic to xicity itself, increased o xidative stress, change in the coagulation cascade, changes in lipid levels and hypervolemia are involved in the genesis of early atherosclerosis in patients with chronic kidney disease. It is incu mbent on clinicians, nephrologists, hypertension specialists, and cardiologists to identify these patients through urinalysis, serum creatinine measurement, and microalbu minuria screening in order to reduce, through intensive treatment, to revert at least in part, the high CVD risk o f that diseased portion of the population." @default.
• W2137240047 created "2016-06-24" @default.
• W2137240047 creator A5002507637 @default.
• W2137240047 creator A5038783986 @default.
• W2137240047 date "2005-12-01" @default.
• W2137240047 modified "2023-10-17" @default.
• W2137240047 title "A doença renal como fator de risco cardiovascular" @default.
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• W2137240047 doi "https://doi.org/10.1590/s0066-782x2005001900011" @default.
• W2137240047 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16429206" @default.
• W2137240047 hasPublicationYear "2005" @default.
• W2137240047 type Work @default.
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