Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137241299> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2137241299 abstract "Recently, the role of tumor microenvironment (niche) in regulating cancer progression has been indicated. Tumor microenvironments consists of tumor vasculature, bone marrow mesenchymal stem cells, immune cells and the components of the extracellular matrix. It is believed that the phenotypic advantages acquired by tumor cells are partly the outcome of their interaction with their niche. Endothelial cells are the building blocks of tumor vasculature and have lately been shown to have additional benefits than merely a conduit for supplying oxygen and nutrients. Here, we intend to demonstrate the critical role of the Akt-activated endothelial (E4ORF1) cells on breast cancer development, survival and spreading. The effect of E4ORF1 cells on breast cancer (BC) and breast cancer stem cells (BCSC) self-renewal was assessed by co-cultivating E4ORF1 with MDA-MB231 and MCF-7 BC cells under adherent and suspension conditions. BCSC enrichment by E4ORF1 cells was measured by analyzing the CD44+/CD24Low/- population of BC cells by flow cytometry as well as by evaluating the expression of pluripotency markers by RT-PCR. BCSCs resistance to treatment was investigated by addition of metformin and determining BCSC proliferation with/out E4ORF1. The role of E4ORF1 on BC cell metastasis was shown by migration and adhesion potential of BC cells with/out E4ORF1 cells. Our results demonstrated a 5-fold increase in the self-renewal capacity of BC cells and BCSCs in the presence of E4ORF1. Also, E4ORF1 was able to promote stemness in BC cells as was shown by significant increase in CD44+/CD24Low/- BCSC population and the up-regulation of pluripotency markers. Moreover, BCSCs survived drug treatment by 2.5 folds in the presence of E4ORF1. Besides, BC cells showed enhanced invasion/adhesion property when exposed to E4ORF1 cells. Our data suggest a major role for E4ORFl cells in BC progression, stemness, resistance and metastasis. This characteristic of E4ORF1 cells in maintaining BC cells can be exploited in developing novel anti-cancer therapy to combat BC in a more effective way." @default.
- W2137241299 created "2016-06-24" @default.
- W2137241299 creator A5007608351 @default.
- W2137241299 creator A5040342571 @default.
- W2137241299 creator A5069596395 @default.
- W2137241299 creator A5079508735 @default.
- W2137241299 date "2012-01-01" @default.
- W2137241299 modified "2023-09-28" @default.
- W2137241299 title "Akt-activated endothelial cells enhance self-renewal, stemness, resistance to therapy, and metastasis in breast cancer" @default.
- W2137241299 doi "https://doi.org/10.5339/qfarf.2012.bmp94" @default.
- W2137241299 hasPublicationYear "2012" @default.
- W2137241299 type Work @default.
- W2137241299 sameAs 2137241299 @default.
- W2137241299 citedByCount "0" @default.
- W2137241299 crossrefType "proceedings-article" @default.
- W2137241299 hasAuthorship W2137241299A5007608351 @default.
- W2137241299 hasAuthorship W2137241299A5040342571 @default.
- W2137241299 hasAuthorship W2137241299A5069596395 @default.
- W2137241299 hasAuthorship W2137241299A5079508735 @default.
- W2137241299 hasConcept C121608353 @default.
- W2137241299 hasConcept C1491633281 @default.
- W2137241299 hasConcept C203014093 @default.
- W2137241299 hasConcept C2776107976 @default.
- W2137241299 hasConcept C2779013556 @default.
- W2137241299 hasConcept C2780932548 @default.
- W2137241299 hasConcept C28328180 @default.
- W2137241299 hasConcept C2908647359 @default.
- W2137241299 hasConcept C502942594 @default.
- W2137241299 hasConcept C54355233 @default.
- W2137241299 hasConcept C55427017 @default.
- W2137241299 hasConcept C55493867 @default.
- W2137241299 hasConcept C71924100 @default.
- W2137241299 hasConcept C86803240 @default.
- W2137241299 hasConcept C8891405 @default.
- W2137241299 hasConcept C95444343 @default.
- W2137241299 hasConcept C96232424 @default.
- W2137241299 hasConcept C99454951 @default.
- W2137241299 hasConceptScore W2137241299C121608353 @default.
- W2137241299 hasConceptScore W2137241299C1491633281 @default.
- W2137241299 hasConceptScore W2137241299C203014093 @default.
- W2137241299 hasConceptScore W2137241299C2776107976 @default.
- W2137241299 hasConceptScore W2137241299C2779013556 @default.
- W2137241299 hasConceptScore W2137241299C2780932548 @default.
- W2137241299 hasConceptScore W2137241299C28328180 @default.
- W2137241299 hasConceptScore W2137241299C2908647359 @default.
- W2137241299 hasConceptScore W2137241299C502942594 @default.
- W2137241299 hasConceptScore W2137241299C54355233 @default.
- W2137241299 hasConceptScore W2137241299C55427017 @default.
- W2137241299 hasConceptScore W2137241299C55493867 @default.
- W2137241299 hasConceptScore W2137241299C71924100 @default.
- W2137241299 hasConceptScore W2137241299C86803240 @default.
- W2137241299 hasConceptScore W2137241299C8891405 @default.
- W2137241299 hasConceptScore W2137241299C95444343 @default.
- W2137241299 hasConceptScore W2137241299C96232424 @default.
- W2137241299 hasConceptScore W2137241299C99454951 @default.
- W2137241299 hasLocation W21372412991 @default.
- W2137241299 hasOpenAccess W2137241299 @default.
- W2137241299 hasPrimaryLocation W21372412991 @default.
- W2137241299 hasRelatedWork W1986055118 @default.
- W2137241299 hasRelatedWork W2012695861 @default.
- W2137241299 hasRelatedWork W2021958215 @default.
- W2137241299 hasRelatedWork W2031583966 @default.
- W2137241299 hasRelatedWork W2045989385 @default.
- W2137241299 hasRelatedWork W2486268594 @default.
- W2137241299 hasRelatedWork W2565163655 @default.
- W2137241299 hasRelatedWork W2637414492 @default.
- W2137241299 hasRelatedWork W2761303431 @default.
- W2137241299 hasRelatedWork W2773652051 @default.
- W2137241299 hasRelatedWork W2887627051 @default.
- W2137241299 hasRelatedWork W2901676414 @default.
- W2137241299 hasRelatedWork W2945196177 @default.
- W2137241299 hasRelatedWork W2963255447 @default.
- W2137241299 hasRelatedWork W2969078627 @default.
- W2137241299 hasRelatedWork W3032598755 @default.
- W2137241299 hasRelatedWork W3110697821 @default.
- W2137241299 hasRelatedWork W3145620386 @default.
- W2137241299 hasRelatedWork W3158127990 @default.
- W2137241299 hasRelatedWork W3214703276 @default.
- W2137241299 isParatext "false" @default.
- W2137241299 isRetracted "false" @default.
- W2137241299 magId "2137241299" @default.
- W2137241299 workType "article" @default.