FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137245835> ?p ?o ?g. }

• W2137245835 endingPage "635" @default.
• W2137245835 startingPage "629" @default.
• W2137245835 abstract "Exposure to carcinogenic polycyclic aromatic hydrocarbons (PAHs) induces cytochrome P450 (CYP) 1A1 and 1B1 enzymes, which biotransform PAHs resulting in the formation of DNA adducts. We hypothesised that 2,3',4,5'-tetramethoxystilbene (TMS), an analogue of resveratrol and a potent CYP1B1 inhibitor, may inhibit r7, t8, t9-trihydroxy-c-10-(N(2)deoxyguanosyl)-7,8,9,10-tetrahydro-benzo[a]pyrene (BPdG) adduct formation in cells exposed to benzo[a]pyrene (BP). To address this, MCF-7 cells were cultured for 96 h in the presence of 1 μM BP, 1 μM BP + 1 μM TMS or 1 μM BP + 4 μM TMS. Cells were assayed at 2-12 h intervals for: BPdG adducts by r7, t8-dihydroxy-t-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE)-DNA chemiluminescence immunoassay; CYP1A1 and 1B1 gene expression changes by relative real-time polymerase chain reaction; and CYP1A1/1B1 enzyme activity by ethoxyresorufin-O-deethylase (EROD) assay. Whereas maximal BPdG levels were similar for all exposure groups, the times at which the maxima were reached increased by 16 and 24 h with the addition of 1 and 4 μM TMS, respectively. The maximal expression of CYP1A1 and CYP1B1 occurred at 16, 24 and 48 h, but the maximal level for EROD-specific activity was reached at 24, 48 and 60 h, in cells exposed to 1 μM BP, 1 μM BP + 1 μM TMS or 1 μM BP + 4 μM TMS, respectively. The area under the curve from 4 to 96 h of exposure (AUC(4-)(96 h)) for BPdG adduct formation was not increased in the presence of TMS, but for CYP1A1 and CYP1B1 expression fold increase AUC(4-)(96 h) and EROD-specific activity AUC(4-)(96 h), there were significant (P < 0.05) increases in the presence of 4 μM TMS. Therefore, during 96 h of exposure in MCF-7 cells, the combination of BP plus TMS caused a slowing of BP biotransformation, with an increase in CYP1A1 and CYP1B1 expression and EROD activity, and a slowing, but no change in magnitude of BPdG formation." @default.
• W2137245835 created "2016-06-24" @default.
• W2137245835 creator A5016404185 @default.
• W2137245835 creator A5067124017 @default.
• W2137245835 creator A5080412801 @default.
• W2137245835 date "2011-06-13" @default.
• W2137245835 modified "2023-09-23" @default.
• W2137245835 title "The resveratrol analogue, 2,3',4,5'-tetramethoxystilbene, does not inhibit CYP gene expression, enzyme activity and benzo[a]pyrene-DNA adduct formation in MCF-7 cells exposed to benzo[a]pyrene" @default.
• W2137245835 cites W1917370654 @default.
• W2137245835 cites W1967023253 @default.
• W2137245835 cites W1981398318 @default.
• W2137245835 cites W1987573118 @default.
• W2137245835 cites W1992744358 @default.
• W2137245835 cites W1999163677 @default.
• W2137245835 cites W2014013779 @default.
• W2137245835 cites W2014148994 @default.
• W2137245835 cites W2055084808 @default.
• W2137245835 cites W2062093570 @default.
• W2137245835 cites W2062657421 @default.
• W2137245835 cites W2065363595 @default.
• W2137245835 cites W2075287906 @default.
• W2137245835 cites W2080600450 @default.
• W2137245835 cites W2090641061 @default.
• W2137245835 cites W2097529071 @default.
• W2137245835 cites W2101621655 @default.
• W2137245835 cites W2105091840 @default.
• W2137245835 cites W2105402826 @default.
• W2137245835 cites W2122673449 @default.
• W2137245835 cites W2127869527 @default.
• W2137245835 cites W2135389576 @default.
• W2137245835 cites W2136175619 @default.
• W2137245835 cites W2138442205 @default.
• W2137245835 cites W2145337751 @default.
• W2137245835 cites W2146909058 @default.
• W2137245835 cites W2168251468 @default.
• W2137245835 cites W2408840226 @default.
• W2137245835 cites W55624665 @default.
• W2137245835 doi "https://doi.org/10.1093/mutage/ger024" @default.
• W2137245835 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3162036" @default.
• W2137245835 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21669939" @default.
• W2137245835 hasPublicationYear "2011" @default.
• W2137245835 type Work @default.
• W2137245835 sameAs 2137245835 @default.
• W2137245835 citedByCount "12" @default.
• W2137245835 countsByYear W21372458352013 @default.
• W2137245835 countsByYear W21372458352015 @default.
• W2137245835 countsByYear W21372458352016 @default.
• W2137245835 countsByYear W21372458352017 @default.
• W2137245835 countsByYear W21372458352019 @default.
• W2137245835 countsByYear W21372458352020 @default.
• W2137245835 countsByYear W21372458352021 @default.
• W2137245835 countsByYear W21372458352022 @default.
• W2137245835 countsByYear W21372458352023 @default.
• W2137245835 crossrefType "journal-article" @default.
• W2137245835 hasAuthorship W2137245835A5016404185 @default.
• W2137245835 hasAuthorship W2137245835A5067124017 @default.
• W2137245835 hasAuthorship W2137245835A5080412801 @default.
• W2137245835 hasBestOaLocation W21372458351 @default.
• W2137245835 hasConcept C108204754 @default.
• W2137245835 hasConcept C114246631 @default.
• W2137245835 hasConcept C153911025 @default.
• W2137245835 hasConcept C155701950 @default.
• W2137245835 hasConcept C178790620 @default.
• W2137245835 hasConcept C181199279 @default.
• W2137245835 hasConcept C185592680 @default.
• W2137245835 hasConcept C2777538855 @default.
• W2137245835 hasConcept C2778951431 @default.
• W2137245835 hasConcept C526171541 @default.
• W2137245835 hasConcept C55493867 @default.
• W2137245835 hasConcept C71240020 @default.
• W2137245835 hasConcept C86803240 @default.
• W2137245835 hasConceptScore W2137245835C108204754 @default.
• W2137245835 hasConceptScore W2137245835C114246631 @default.
• W2137245835 hasConceptScore W2137245835C153911025 @default.
• W2137245835 hasConceptScore W2137245835C155701950 @default.
• W2137245835 hasConceptScore W2137245835C178790620 @default.
• W2137245835 hasConceptScore W2137245835C181199279 @default.
• W2137245835 hasConceptScore W2137245835C185592680 @default.
• W2137245835 hasConceptScore W2137245835C2777538855 @default.
• W2137245835 hasConceptScore W2137245835C2778951431 @default.
• W2137245835 hasConceptScore W2137245835C526171541 @default.
• W2137245835 hasConceptScore W2137245835C55493867 @default.
• W2137245835 hasConceptScore W2137245835C71240020 @default.
• W2137245835 hasConceptScore W2137245835C86803240 @default.
• W2137245835 hasIssue "5" @default.
• W2137245835 hasLocation W21372458351 @default.
• W2137245835 hasLocation W21372458352 @default.
• W2137245835 hasLocation W21372458353 @default.
• W2137245835 hasLocation W21372458354 @default.
• W2137245835 hasOpenAccess W2137245835 @default.
• W2137245835 hasPrimaryLocation W21372458351 @default.
• W2137245835 hasRelatedWork W1973125771 @default.
• W2137245835 hasRelatedWork W2016081901 @default.
• W2137245835 hasRelatedWork W2032791321 @default.
• W2137245835 hasRelatedWork W2055084808 @default.
• W2137245835 hasRelatedWork W2084587873 @default.
• W2137245835 hasRelatedWork W2092584460 @default.
• W2137245835 hasRelatedWork W2132762752 @default.

• next