Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137253453> ?p ?o ?g. }
- W2137253453 endingPage "31" @default.
- W2137253453 startingPage "25" @default.
- W2137253453 abstract "Motor control demands coordinated excitation and inhibition across distributed brain neuronal networks. Recent work has suggested that multiple sclerosis (MS) may be associated with impairments of neuronal inhibition as part of more general progressive impairments of connectivity. Here, we report results from a prospective, multi-centre fMRI study designed to characterise the changes in patients relative to healthy controls during a simple cued hand movement task. This study was conducted at eight European sites using 1.5 Tesla scanners. Brain deactivation during right hand movement was assessed in 56 right-handed patients with relapsing-remitting or secondary progressive MS without clinically evident hand impairment and in 60 age-matched, healthy subjects. The MS patients showed reduced task-associated deactivation relative to healthy controls in the pre- and postcentral gyri of the ipsilateral hemisphere in the region functionally specialised for hand movement control. We hypothesise that this impairment of deactivation is related to deficits of transcallosal connectivity and GABAergic neurotransmission occurring with the progression of pathology in the MS patients. This study has substantially extended previous observations with a well-powered, multicentre study. The clinical significance of these deactivation changes is still uncertain, but the functional anatomy of the affected region suggests that they could contribute to impairments of motor control." @default.
- W2137253453 created "2016-06-24" @default.
- W2137253453 creator A5003010065 @default.
- W2137253453 creator A5006100482 @default.
- W2137253453 creator A5009974045 @default.
- W2137253453 creator A5010641303 @default.
- W2137253453 creator A5020136275 @default.
- W2137253453 creator A5020377507 @default.
- W2137253453 creator A5020619868 @default.
- W2137253453 creator A5024199819 @default.
- W2137253453 creator A5024718915 @default.
- W2137253453 creator A5026509971 @default.
- W2137253453 creator A5028519399 @default.
- W2137253453 creator A5030823525 @default.
- W2137253453 creator A5031171090 @default.
- W2137253453 creator A5057492639 @default.
- W2137253453 creator A5057796353 @default.
- W2137253453 creator A5059319555 @default.
- W2137253453 creator A5063275381 @default.
- W2137253453 creator A5064378373 @default.
- W2137253453 creator A5064851379 @default.
- W2137253453 creator A5066195949 @default.
- W2137253453 creator A5066553010 @default.
- W2137253453 creator A5067383775 @default.
- W2137253453 creator A5069286491 @default.
- W2137253453 creator A5070289069 @default.
- W2137253453 creator A5073654164 @default.
- W2137253453 creator A5076669758 @default.
- W2137253453 creator A5083676325 @default.
- W2137253453 creator A5084674707 @default.
- W2137253453 creator A5086704382 @default.
- W2137253453 creator A5087281021 @default.
- W2137253453 creator A5090408250 @default.
- W2137253453 date "2008-01-31" @default.
- W2137253453 modified "2023-10-18" @default.
- W2137253453 title "Impairment of movement-associated brain deactivation in multiple sclerosis: further evidence for a functional pathology of interhemispheric neuronal inhibition" @default.
- W2137253453 cites W1967822215 @default.
- W2137253453 cites W1967825340 @default.
- W2137253453 cites W1976891377 @default.
- W2137253453 cites W1979560785 @default.
- W2137253453 cites W1991660386 @default.
- W2137253453 cites W1996000392 @default.
- W2137253453 cites W2000567868 @default.
- W2137253453 cites W2003295446 @default.
- W2137253453 cites W2008501843 @default.
- W2137253453 cites W2008833275 @default.
- W2137253453 cites W2010087890 @default.
- W2137253453 cites W2018102971 @default.
- W2137253453 cites W2022050192 @default.
- W2137253453 cites W2023536729 @default.
- W2137253453 cites W2030261869 @default.
- W2137253453 cites W2035001644 @default.
- W2137253453 cites W2035040175 @default.
- W2137253453 cites W2038506425 @default.
- W2137253453 cites W2043161114 @default.
- W2137253453 cites W2044634376 @default.
- W2137253453 cites W2051351274 @default.
- W2137253453 cites W2060275991 @default.
- W2137253453 cites W2063890844 @default.
- W2137253453 cites W2069565484 @default.
- W2137253453 cites W2070326044 @default.
- W2137253453 cites W2072090988 @default.
- W2137253453 cites W2098406191 @default.
- W2137253453 cites W2100605312 @default.
- W2137253453 cites W2108489837 @default.
- W2137253453 cites W2109015752 @default.
- W2137253453 cites W2112165124 @default.
- W2137253453 cites W2118090476 @default.
- W2137253453 cites W2119792333 @default.
- W2137253453 cites W2129375200 @default.
- W2137253453 cites W2130355701 @default.
- W2137253453 cites W2132724157 @default.
- W2137253453 cites W2134858198 @default.
- W2137253453 cites W2136687362 @default.
- W2137253453 cites W2137526583 @default.
- W2137253453 cites W2139843103 @default.
- W2137253453 cites W2141585509 @default.
- W2137253453 cites W2143285014 @default.
- W2137253453 cites W2148726987 @default.
- W2137253453 cites W2168430251 @default.
- W2137253453 cites W2171447350 @default.
- W2137253453 cites W4235770099 @default.
- W2137253453 doi "https://doi.org/10.1007/s00221-008-1276-1" @default.
- W2137253453 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2414440" @default.
- W2137253453 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18236036" @default.
- W2137253453 hasPublicationYear "2008" @default.
- W2137253453 type Work @default.
- W2137253453 sameAs 2137253453 @default.
- W2137253453 citedByCount "53" @default.
- W2137253453 countsByYear W21372534532012 @default.
- W2137253453 countsByYear W21372534532013 @default.
- W2137253453 countsByYear W21372534532014 @default.
- W2137253453 countsByYear W21372534532015 @default.
- W2137253453 countsByYear W21372534532016 @default.
- W2137253453 countsByYear W21372534532018 @default.
- W2137253453 countsByYear W21372534532019 @default.
- W2137253453 countsByYear W21372534532020 @default.
- W2137253453 countsByYear W21372534532021 @default.